Ethanamine, 2,2-dimethoxy-N,N-dimethyl-

Base Information

• Chemical Name: Ethanamine, 2,2-dimethoxy-N,N-dimethyl-
• CAS No.: 38711-20-5
• Molecular Formula: C6H15NO2
• Molecular Weight: 133.191
• Hs Code.: 29110000
• European Community (EC) Number: 254-097-1
• DSSTox Substance ID: DTXSID7068134
• Nikkaji Number: J97.890F
• Wikidata: Q72467895
• Mol file: 38711-20-5.mol

Synonyms:38711-20-5;2,2-Dimethoxy-N,N-dimethylethanamine;Dimethylaminoacetaldehyde dimethylacetal;Ethanamine, 2,2-dimethoxy-N,N-dimethyl-;Dimethylaminoacetaldehyde dimethyl acetal;(Dimethylamino)acetaldehyde Dimethyl Acetal;N-(2,2-Dimethoxyethyl)dimethylamine;2,2-Dimethoxyethyl(dimethyl)amine;EINECS 254-097-1;MFCD00010205;2-(Dimethylamino)acetaldehyde dimethylacetal;(2,2-dimethoxyethyl)dimethylamine;2,2-Dimethoxy-N,N-dimethylethylamine;DIMETHYLAMINOACETALDEHYDEDIMETHYLACETAL;SCHEMBL2503689;DTXSID7068134;AKOS005256244;Dimethylaminoacetaldehydedimethyl acetal;CS-W011080;FS-4307;(Dimethylamino)acetaldehyde dimethylacetal;D1704;FT-0625118;EN300-1699290

Chemical Property of Ethanamine, 2,2-dimethoxy-N,N-dimethyl-

Chemical Property:

• Appearance/Colour: Clear colorless liquid
• Vapor Pressure: 1.86mmHg at 25°C
• Refractive Index: 1.423
• Boiling Point: 141.8 °C at 760 mmHg
• PKA: 9.35±0.28(Predicted)
• Flash Point: 32.2 °C
• PSA: 21.70000
• Density: 0.9 g/cm³
• LogP: 0.16690
• Storage Temp.: Flammables area
• Sensitive.: Moisture Sensitive
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 133.110278721
• Heavy Atom Count: 9
• Complexity: 62.1

Purity/Quality:

99% ^*data from raw suppliers

(Dimethylamino)acetaldehyde Dimethyl Acetal >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-36/37/38-34
• Safety Statements: 26-36/37/39-45-16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CC(OC)OC

Technology Process of Ethanamine, 2,2-dimethoxy-N,N-dimethyl-

There total 2 articles about Ethanamine, 2,2-dimethoxy-N,N-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-2,2-dimethoxyethane (7252-83-7) + dimethyl amine (124-40-3) → 1,1-dimethoxymethyl-N,N-dimethylmethanamine (38711-20-5)

Guidance literature:

With benzene;

Reference yield:

chloroacetaldehyde dimethyl acetal (97-97-2) + dimethyl amine (124-40-3) → 1,1-dimethoxymethyl-N,N-dimethylmethanamine (38711-20-5)

Guidance literature:

With ethanol; at 140 ℃;

DOI:10.1039/jr9550002896

Reference yield: 61.0%

1,1-dimethoxymethyl-N,N-dimethylmethanamine (38711-20-5) + N-Benzylidenebenzylamine N-oxide (3376-26-9) → C20H28N2O3

Guidance literature:

With 4,4'-Dichlorobenzophenone; In acetone; at 20 ℃; for 2h; regioselective reaction; Inert atmosphere; UV-irradiation;

DOI:10.1039/c5ob01277e

upstream raw materials:

1-bromo-2,2-dimethoxyethane

dimethyl amine

chloroacetaldehyde dimethyl acetal

Downstream raw materials:

2-(N,N-dimethylamino)ethoxide

2-(dimethylamino)-acetaldehyde hydrochloride

tert-butyl (3R)-3-{[2-(dimethylamino)ethyl]amino}piperidine-1-carboxylate

N′-carbamothioyl-N,N-dimethylformimidamide

Refernces

• 1、 Xia, Guangxin,Chen, Wenteng,Zhang, Jing,Shao, Jiaan,Zhang, Yong,Huang, Wei,Zhang, Leduo,Qi, Weixing,Sun, Xing,Li, Bojun,Xiang, Zhixiong,Ma, Chen,Xu, Jia,Deng, Hailin,Li, Yufeng,Li, Ping,Miao, Hong,Han, Jiansheng,Liu, Yanjun,Shen, Jingkang,Yu, Yongping. "A chemical tuned strategy to develop novel irreversible EGFR-TK inhibitors with improved safety and pharmacokinetic profiles". . p. 9889 - 9900. Retrieved 2015/02/02.