(4-Methoxyphenyl)(phenyl)methanol

Base Information

• Chemical Name: (4-Methoxyphenyl)(phenyl)methanol
• CAS No.: 720-44-5
• Molecular Formula: C14H14O2
• Molecular Weight: 214.264
• Hs Code.: 2909499000
• European Community (EC) Number: 211-953-9
• NSC Number: 5186
• DSSTox Substance ID: DTXSID30903232
• Nikkaji Number: J193.092C
• Wikidata: Q106902775
• Mol file: 720-44-5.mol

Synonyms:4-Methoxybenzhydrol;(4-Methoxyphenyl)(phenyl)methanol;720-44-5;(4-methoxyphenyl)-phenylmethanol;4-Methoxybenzhydryl alcohol;EINECS 211-953-9;Benzenemethanol, 4-methoxy-.alpha.-phenyl-;(4-Methoxy-phenyl)-phenyl-methanol;NSC5186;Benzenemethanol,4-methoxy-a-phenyl-;4-Methoxybenzohydrol;NoName_3861;p-methoxybenzhydryl alcohol;DL-4-METHOXYBENZHYDROL;SCHEMBL477621;DTXSID30903232;NSC 5186;NSC-5186;(4-Methoxyphenyl)(phenyl)methanol #;BBL036017;MFCD00014398;STK022522;AKOS005379031;Benzenemethanol, 4-methoxy-alpha-phenyl-;AC-20896;CS-0093480;FT-0618918;M1278;D75401;AE-641/00008036

Chemical Property of (4-Methoxyphenyl)(phenyl)methanol

Chemical Property:

• Vapor Pressure: 6.55E-06mmHg at 25°C
• Melting Point: 67-69 °C
• Refractive Index: 1.582
• Boiling Point: 363.2 °C at 760 mmHg
• PKA: 13.61±0.20(Predicted)
• Flash Point: 164.5 °C
• PSA: 29.46000
• Density: 1.121 g/cm³
• LogP: 2.77690
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 214.099379685
• Heavy Atom Count: 16
• Complexity: 191

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxybenzhydrol ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)O

Technology Process of (4-Methoxyphenyl)(phenyl)methanol

There total 214 articles about (4-Methoxyphenyl)(phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C6H5BrMg*ClLi + 4-methoxy-benzaldehyde (123-11-5) → 4-Methoxybenzophenone (611-94-9) + 1-(4-methoxyphenyl)-1-phenylmethanol (720-44-5)

Guidance literature:

C₆H₅BrMg*ClLi; With EtZnOMe; at 0 ℃; for 0.166667h; Inert atmosphere;

4-methoxy-benzaldehyde; With pivalaldehyde; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/aoc.4462

Reference yield: 78.0%

C6H5IMg*LiCl + 4-methoxy-benzaldehyde (123-11-5) → 4-Methoxybenzophenone (611-94-9) + 1-(4-methoxyphenyl)-1-phenylmethanol (720-44-5)

Guidance literature:

C₆H₅IMg*LiCl; With methyl zinc ⁽¹⁺⁾; methylate; at 0 ℃; for 0.166667h; Inert atmosphere;

4-methoxy-benzaldehyde; With pivalaldehyde; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/aoc.4462

Reference yield: 75.0%

benzaldehyde (100-52-7) + (4-methoxyphenyl)(ethyl)silanediol (297163-77-0) → 4-Methoxybenzophenone (611-94-9) + 1-(4-methoxyphenyl)-1-phenylmethanol (720-44-5)

Guidance literature:

[Rh(OH)(cod)]2; In 1,4-dioxane; at 100 ℃;

DOI:10.1055/s-2002-19786

upstream raw materials:

4-Methoxybenzophenone

(+/-)-phthalic acid mono-(4-methoxy-benzhydryl ester)

4-methoxy-benzaldehyde

sodium isopropylate

Downstream raw materials:

1-((4-methoxyphenyl)((4-methoxyphenyl)(phenyl)methoxy)methyl)benzene

Medrylamin

Oxalsaeure-di-(4-methoxy-benzhydryl-ester)

4-Methoxybenzhydryl-N-phenylcarbamat

Refernces

• 1、 Botubol-Ares, José Manuel,Cordón-Ouahhabi, Safa,Moutaoukil, Zakaria,Collado, Isidro G.,Jiménez-Tenorio, Manuel,Puerta, M. Carmen,Valerga, Pedro. "Methylene-Linked Bis-NHC Half-Sandwich Ruthenium Complexes: Binding of Small Molecules and Catalysis toward Ketone Transfer Hydrogenation". supporting information. p. 792 - 803. Retrieved 2021/04/06.
• 2、 Ana, Gloria,Kelly, Patrick M.,Malebari, Azizah M.,Noorani, Sara,Nathwani, Seema M.,Twamley, Brendan,Fayne, Darren,O’boyle, Niamh M.,Zisterer, Daniela M.,Pimentel, Elisangela Flavia,Endringer, Denise Coutinho,Meegan, Mary J.. "Synthesis and biological evaluation of 1‐(Diarylmethyl)‐1h‐1,2,4‐triazoles and 1‐(diarylmethyl)‐1h‐imidazoles as a novel class of anti‐mitotic agent for activity in breast cancer". . p. 1 - 59. Retrieved 2021/03/16.