Methyl 4-(hydroxyMethyl)bicyclo[2.2.2]octane-1-carboxylate

Base Information

• Chemical Name: Methyl 4-(hydroxyMethyl)bicyclo[2.2.2]octane-1-carboxylate
• CAS No.: 94994-15-7
• Molecular Formula: C11H18O3
• Molecular Weight: 198.262
• Hs Code.: 2918199090
• Mol file: 94994-15-7.mol

Synonyms:4-carbomethoxybicyclo<2.2.2>octane-1-methanol;

Chemical Property of Methyl 4-(hydroxyMethyl)bicyclo[2.2.2]octane-1-carboxylate

Chemical Property:

• Vapor Pressure: 0.000704mmHg at 25°C
• Boiling Point: 274.1oC at 760 mmHg
• Flash Point: 108.7oC
• PSA: 46.53000
• Density: 1.175g/cm3
• LogP: 1.49230
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl 4-(hydroxymethyl)bicyclo[2.2.2]octane-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-(hydroxyMethyl)bicyclo[2.2.2]octane-1-carboxylate

There total 18 articles about Methyl 4-(hydroxyMethyl)bicyclo[2.2.2]octane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.35%

bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester (18720-35-9) → 4-hydroxymethyl-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester (94994-15-7)

Guidance literature:

bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester; In tetrahydrofuran; at 0 - 25 ℃; for 12h;

With methanol; In tetrahydrofuran; at 10 - 25 ℃; for 2h;

Reference yield: 91.0%

bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester (18720-35-9) + chloroformic acid ethyl ester (541-41-3) → 4-hydroxymethyl-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester (94994-15-7)

Guidance literature:

bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester; chloroformic acid ethyl ester; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

With sodium tetrahydroborate; In tetrahydrofuran; water; at 0 - 20 ℃; for 1h;

Reference yield:

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate (1459-96-7) → Bicyclo<2.2.2>octane-1,4-dimethanol (826-45-9) + 4-hydroxymethyl-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester (94994-15-7)

Guidance literature:

With [2-(di-tert-butylphosphinomethyl)-6-(diethylaminomethyl)pyridine]carbonylchlorohydridoruthenium (ll); hydrogen; potassium hydroxide; In para-xylene; at 140 ℃; for 8h; under 39547.2 - 52476.2 Torr; Temperature; Pressure; Reagent/catalyst; Autoclave;

upstream raw materials:

bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester

dimethyl 1,4-cyclohexane dicarboxylate

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate

methyl 4-phenylbicyclo<2.2.2>octane-1-carboxylate

Downstream raw materials:

4-carbomethoxybicyclo<2.2.2>octane-1-carboxaldehyde

C₂₄H₃₃NO₅

3-(4-(6-amino-2,4-dioxo-1-propyl-3-heptadeuteriopropyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-bicyclo[2.2.2]oct-1-yl)propionic acid methyl ester

4-formyl-bicyclo[2.2.2]octane-1-carboxylic acid

Refernces

• 1、 -. "SSAO INHIBITORS AND USE THEREOF". Paragraph 00274. . Retrieved 2021/05/07.
• 2、 -. "NOVEL AMIDE DERIVATIVE". Paragraph 0079. . Retrieved 2021/08/04.