5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenyl-, 2-furanylmethyl ester

Base Information

Chemical Name:5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenyl-, 2-furanylmethyl ester
CAS No.:95928-47-5
Molecular Formula:C18H18N2O4
Molecular Weight:326.352
Hs Code.:

Synonyms:

Suppliers and Price of 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenyl-, 2-furanylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenyl-, 2-furanylmethyl ester

Chemical Property:

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Technology Process of 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenyl-, 2-furanylmethyl ester

There total 3 articles about 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenyl-, 2-furanylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 98-00-0,25212-86-6,93793-62-5
(2-furyl)methyl alcohol

: 60750-38-1
1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenylpyrimidine-5-carboxylic acid

: 95928-47-5
Furfuryl Ester of 1,6-Dimethyl-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 0.00833333h;
DOI:10.1016/j.tet.2005.12.061

Reference yield:

: 5396-89-4
benzyl acetoacetate

: 95928-47-5
Furfuryl Ester of 1,6-Dimethyl-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid

Guidance literature:: Multi-step reaction with 3 steps

1: 36 percent / Yb(OTf)3 / acetonitrile / 0.33 h / 120 °C / microwave irradiation

2: 85 percent / hydrogen; acetic acid / Pd/C / ethanol / 40 - 45 °C / atmospheric pressure

3: 99 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 0.01 h / 20 °C

With di-isopropyl azodicarboxylate; hydrogen; acetic acid; triphenylphosphine; ytterbium(III) triflate; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetonitrile; 1: Biginelli condensation / 3: Mitsunobu esterification;
DOI:10.1016/j.tet.2005.12.061

Reference yield:

: 60750-24-5
benzyl 1,6-dimethyl-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 95928-47-5
Furfuryl Ester of 1,6-Dimethyl-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / hydrogen; acetic acid / Pd/C / ethanol / 40 - 45 °C / atmospheric pressure

2: 99 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 0.01 h / 20 °C

With di-isopropyl azodicarboxylate; hydrogen; acetic acid; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; 2: Mitsunobu esterification;
DOI:10.1016/j.tet.2005.12.061