methyl 2-(1-oxoisoindolin-2-yl)acetate

Base Information

• Chemical Name: methyl 2-(1-oxoisoindolin-2-yl)acetate
• CAS No.: 96017-03-7
• Molecular Formula: C11H11NO3
• Molecular Weight: 205.21000
• Hs Code.: 2933998090
• Mol file: 96017-03-7.mol

Synonyms:N-(methoxycarbonylmethyl)-1-isoindolinone;methyl-2-(1-oxoisoindolin-2-yl)acetate;

Chemical Property of methyl 2-(1-oxoisoindolin-2-yl)acetate

Chemical Property:

• Melting Point: 95 - 106 °C
• PSA: 46.61000
• LogP: 0.75330

Purity/Quality:

99%, ^*data from raw suppliers

methyl2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of methyl 2-(1-oxoisoindolin-2-yl)acetate

There total 2 articles about methyl 2-(1-oxoisoindolin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

carbon monoxide (201230-82-2) + 2-Iodobenzyl bromide (40400-13-3) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → methyl (1-oxo-1,3-dihydro-2H-isoindol-2-yl)acetate (96017-03-7)

Guidance literature:

With palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 50 ℃; for 24h; under 750.075 Torr; chemoselective reaction;

DOI:10.1016/j.tet.2010.11.099

Reference yield: 88.0%

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + o-carboxybenzaldehyde (119-67-5) → methyl (1-oxo-1,3-dihydro-2H-isoindol-2-yl)acetate (96017-03-7)

Guidance literature:

With sodium tris(acetoxy)borohydride; In acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1071/CH12489

Reference yield: 76.0%

methyl (1-oxo-1,3-dihydro-2H-isoindol-2-yl)acetate (96017-03-7) → (1-oxo-1,3-dihydro-2H-isoindol-2-yl)carboxylic acid (39221-42-6)

Guidance literature:

With potassium carbonate; In methanol; water; at 20 ℃;

DOI:10.1021/acs.jmedchem.5b00777

upstream raw materials:

carbon monoxide

2-Iodobenzyl bromide

glycine ethyl ester hydrochloride

o-carboxybenzaldehyde

Downstream raw materials:

2-{2-[4-(4-[18F]-fluorobenzyl)piperazin-1-yl]-2-oxoethyl}isoindolin-1-one

(1-oxo-1,3-dihydro-2H-isoindol-2-yl)carboxylic acid

2-{2-[4-(4-fluorobenzyl)piperazin-1-yl]-2-oxoethyl}isoindolin-1-one

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