2-(3-Methoxy-5-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

Base Information

Chemical Name:2-(3-Methoxy-5-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole
CAS No.:96227-33-7
Molecular Formula:C13H17NO2
Molecular Weight:219.283
Hs Code.:
DSSTox Substance ID:DTXSID90575974

Synonyms:96227-33-7;DTXSID90575974;2-(3-Methoxy-5-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

Suppliers and Price of 2-(3-Methoxy-5-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3-Methoxy-5-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:219.125928785
Heavy Atom Count:16
Complexity:286

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CC(=C1)OC)C2=NC(CO2)(C)C

Technology Process of 2-(3-Methoxy-5-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

There total 7 articles about 2-(3-Methoxy-5-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: N-(2-Hydroxy-1,1-dimethyl-ethyl)-3-methoxy-5-methyl-benzamide

: 96227-33-7
2-(3-methoxy-5-methylphenyl)-4,4-dimethyl-Δ²-oxazoline

Guidance literature:: With thionyl chloride; for 1h; Ambient temperature;
DOI:10.1021/jo00213a015

Reference yield:

: 62089-34-3
3-methoxy-5-methylbenzoic acid

: 96227-33-7
2-(3-methoxy-5-methylphenyl)-4,4-dimethyl-Δ²-oxazoline

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / 24 h / 25 °C

2: 100 percent / CH₂Cl₂ / 24 h / 25 °C

3: 86 percent / SOCl₂ / 1 h / Ambient temperature

With thionyl chloride; In dichloromethane;
DOI:10.1021/jo00213a015

Reference yield:

: 96227-40-6
5-methoxy-3-methylbenzoic acid chloride

: 96227-33-7
2-(3-methoxy-5-methylphenyl)-4,4-dimethyl-Δ²-oxazoline

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / CH₂Cl₂ / 24 h / 25 °C

2: 86 percent / SOCl₂ / 1 h / Ambient temperature

With thionyl chloride; In dichloromethane;
DOI:10.1021/jo00213a015