1,4-Dihydro-4-phenyl-3,5-pyridinedicarboxylic acid dimethyl ester

Base Information

Chemical Name:1,4-Dihydro-4-phenyl-3,5-pyridinedicarboxylic acid dimethyl ester
CAS No.:56820-24-7
Molecular Formula:C15H15NO4
Molecular Weight:273.288
Hs Code.:
NSC Number:173324
DSSTox Substance ID:DTXSID30306022
Nikkaji Number:J957.453K

Synonyms:NSC173324;56820-24-7;DTXSID30306022;NSC-173324

Suppliers and Price of 1,4-Dihydro-4-phenyl-3,5-pyridinedicarboxylic acid dimethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 1,4-Dihydro-4-phenyl-3,5-pyridinedicarboxylic acid dimethyl ester

Chemical Property:

Vapor Pressure:7.38E-07mmHg at 25°C
Boiling Point:407.7°Cat760mmHg
Flash Point:200.4°C
Density:1.217g/cm³
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:273.10010796
Heavy Atom Count:20
Complexity:415

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CNC=C(C1C2=CC=CC=C2)C(=O)OC

Technology Process of 1,4-Dihydro-4-phenyl-3,5-pyridinedicarboxylic acid dimethyl ester

There total 6 articles about 1,4-Dihydro-4-phenyl-3,5-pyridinedicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 100-52-7
benzaldehyde

: 922-67-8
propynoic acid methyl ester

: 56820-24-7
dimethyl-1,4-dihydro-4-phenyl-pyridine-3,5-dicarboxylate

Guidance literature:: With 1?(1?carboxymethyl)?3?methylimidazolium tetrafluoroborate; ammonium carbonate; In neat (no solvent); at 60 ℃; for 0.0833333h; Temperature; Reagent/catalyst; Sonication; Green chemistry;
DOI:10.1016/j.ultsonch.2014.05.026

Reference yield: 80.0%

: 124-41-4
sodium methylate

: 219786-83-1
4-Phenyl-5-(2,2,2-trichloro-acetyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

: 56820-24-7
dimethyl-1,4-dihydro-4-phenyl-pyridine-3,5-dicarboxylate

Guidance literature:: In methanol;
DOI:10.1016/S0040-4039(98)02084-X

Reference yield:

: 93-60-7
methyl 3-pyridinecarboxylate

: 56820-24-7
dimethyl-1,4-dihydro-4-phenyl-pyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

2: 2.) TBAF / 1.) THF, -40 deg C; 2.) THF, -40 deg C to 0 deg C

3: tetrahydrofuran / 2 h / 0 °C

4: 80 percent / methanol

With tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(98)02084-X