3-Quinolinecarboxylic acid, 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester

Base Information

Chemical Name:3-Quinolinecarboxylic acid, 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester
CAS No.:98105-80-7
Molecular Formula:C18H12ClF2NO3
Molecular Weight:363.748
Hs Code.:

Synonyms:7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid,ethyl ester;7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, ethyl ester;

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Chemical Property of 3-Quinolinecarboxylic acid, 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester

Chemical Property:

Boiling Point:497.4±45.0 °C(Predicted)
PSA：48.30000
Density:1.433±0.06 g/cm3(Predicted)
LogP:4.09900

Purity/Quality:

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Technology Process of 3-Quinolinecarboxylic acid, 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester

There total 5 articles about 3-Quinolinecarboxylic acid, 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 98105-65-8
ethyl 2,4-dichloro-5-fluoro-α-[[(4-fluorophenyl)amino]methylene]-β-oxobenzenepropanoate

: 98105-80-7
1-(4'-fluoro-phenyl)-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/S0040-4039(00)82082-1

Reference yield:

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 98105-80-7
1-(4'-fluoro-phenyl)-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / NaH / 1.5 h / 80 °C

2: Ac₂O / 2 h / 130 °C

3: CH₂Cl₂ / 0.5 h / Ambient temperature

4: NaH / 1,2-dimethoxy-ethane / 3 h / 80 °C

With acetic anhydride; sodium hydride; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm00149a003

Reference yield:

: 86483-51-4
ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate

: 98105-80-7
1-(4'-fluoro-phenyl)-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Ac₂O / 2 h / 130 °C

2: CH₂Cl₂ / 0.5 h / Ambient temperature

3: NaH / 1,2-dimethoxy-ethane / 3 h / 80 °C

With acetic anhydride; sodium hydride; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm00149a003