N-(adamantan-1-yl)quinoxaline-2-carboxamide

Base Information

Chemical Name:N-(adamantan-1-yl)quinoxaline-2-carboxamide
CAS No.:226878-01-9
Molecular Formula:C19H21N3O
Molecular Weight:307.39872
Hs Code.:
DSSTox Substance ID:DTXSID10427729
Nikkaji Number:J3.046.691H
Wikidata:Q27088035
Pharos Ligand ID:5A8JDDJMB4DD
ChEMBL ID:CHEMBL399160
Mol file:226878-01-9.mol

Synonyms:2-quinoxaline-carboxamide-N-adamantan-1-yl;NPS 2390;NPS-2390;NPS2390

Suppliers and Price of N-(adamantan-1-yl)quinoxaline-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
NPS2390
5mg
$ 75.00

TRC
NPS2390
1mg
$ 45.00

CSNpharm
NPS2390
50mg
$ 604.00

Cayman Chemical
NPS 2390 ≥98%
10mg
$ 137.00

Cayman Chemical
NPS 2390 ≥98%
5mg
$ 72.00

Cayman Chemical
NPS 2390 ≥98%
25mg
$ 324.00

ApexBio Technology
NPS2390
10mg
$ 282.00

ApexBio Technology
NPS2390
50mg
$ 1190.00

American Custom Chemicals Corporation
NPS 2390 95.00%
25MG
$ 906.53

American Custom Chemicals Corporation
NPS 2390 95.00%
5MG
$ 203.50

Total 12 raw suppliers

Chemical Property of N-(adamantan-1-yl)quinoxaline-2-carboxamide

Chemical Property:

PSA：54.88000
LogP:3.71930
Storage Temp.:2-8°C
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:307.168462302
Heavy Atom Count:23
Complexity:450

Purity/Quality:

99%, ^*data from raw suppliers

NPS2390 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1C2CC3CC1CC(C2)(C3)NC(=O)C4=NC5=CC=CC=C5N=C4
Description Metabotropic glutamate receptors (mGluRs), mediate excitatory synaptic transmission in the central nervous system. Potent and selective antagonists of the type I mGluRs (mGluR1 and mGluR5) are of interest as novel therapeutics for the treatment of various CNS disorders, such as pain, epilepsy, and stroke. NPS 2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 with IC50 values equal to 5.2 and 82 nM, respectively). At concentrations up to 30 μM, NPS 2390 does not affect mGluR2 or mGluR8 or a standard collection of 37 additional receptors, ion channels, and enzymes. At a dose of 10 mg/kg, NPS 2390 displaced the specifically bound mGlu1R-selective antagonist, [3H]R214127, in rat cerebellum.
Uses Metabotropic glutamate receptors (mGluRs), mediate excitatory synaptic transmission in the central nervous system. Potent and selective antagonists of the type I mGluRs (mGluR1 and mGluR5) are of interest as novel therapeutics for the treatment of various CNS disorders, such as pain, epilepsy, and stroke. NPS 2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 with IC50 values equal to 5.2 and 82 nM, respectively). At concentrations up to 30 μM, NPS 2390 does not affect mGluR2 or mGluR8 or a standard collection of 37 additional receptors, ion channels, and enzymes. At a dose of 10 mg/kg, NPS 2390 displaced the specifically bound mGlu1R-selective antagonist, [3H]R214127, in rat cerebellum. NPS 2390 is an inhibitor of CaSR (Calcium-sensing recpetor). NPS 2390 up-regulated anti-apoptotic protein Bcl-2 expression and down-regulated pro-apoptotic protein Bax.

Technology Process of N-(adamantan-1-yl)quinoxaline-2-carboxamide

There total 1 articles about N-(adamantan-1-yl)quinoxaline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: