Technology Process of 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one
There total 10 articles about 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
methanol;
at 20 ℃;
for 4h;
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; tert-butyl XPhos;
In
1,4-dioxane;
at 100 ℃;
for 6h;
DOI:10.1021/jm101144f
- Guidance literature:
-
Multi-step reaction with 7 steps
1: tetrahydrofuran / 0.25 h / 120 °C / Microwave irradiation
2: sodium tetrahydroborate; ethanol / 4 h / 20 °C
3: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
4: potassium carbonate / ethanol / 0.25 h / 150 °C / Microwave irradiation
5: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 0.17 h / 150 °C / Microwave irradiation
6: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 20 °C
7: triethylamine / methanol / 4 h / 20 °C
With
sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0); ethanol; sodium carbonate; potassium carbonate; Dess-Martin periodane; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
