N-(3-(2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide

Base Information

Chemical Name:N-(3-(2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide
CAS No.:1625677-48-6
Molecular Formula:C₃₀H₃₁N₇O₄
Molecular Weight:553.621
Hs Code.:

Synonyms:N-(3-(2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide

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Chemical Property of N-(3-(2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide

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Technology Process of N-(3-(2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide

There total 14 articles about N-(3-(2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1021426-42-5
1-(4-{4-amino-3-methoxyphenyl}piperazine-1-yl)ethan-1-one

: 1625678-21-8
N-(3-(5-methyl-2-(methylsulfinyl)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide

: 1625677-48-6
N-(3-(2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; tert-butyl alcohol; at 110 ℃; for 72h; Sealed tube;

Reference yield:

: 1625678-19-4
N-(3-(5-methyl-2-S₈(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide

: 1625677-48-6
N-(3-(2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol; 1,4-dioxane / 72 h / 110 °C / Sealed tube

With N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane; tert-butyl alcohol;

Reference yield:

: 1584151-18-7
tert-butyl (3-((5-acetyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

: 1625677-48-6
N-(3-(2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

1.2: 3 h / -78 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.42 h / 0 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C

5.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol; 1,4-dioxane / 72 h / 110 °C / Sealed tube

With N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; tert-butyl alcohol;