1-(4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl)ethanone

Base Information

• Chemical Name: 1-(4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl)ethanone
• CAS No.: 1116229-11-8
• Molecular Formula: C13H17N3O4
• Molecular Weight: 279.296
• Mol file: 1116229-11-8.mol

Synonyms:1-(4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl)ethanone;1-acetyl-4-[3-(methyloxy)-4-nitrophenyl]piperazine

Chemical Property of 1-(4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl)ethanone

Chemical Property:

• Boiling Point: 510.9±50.0 °C(Predicted)
• PKA: 1.19±0.20(Predicted)
• PSA: 78.60000
• Density: 1.270±0.06 g/cm3(Predicted)
• LogP: 1.79800

Purity/Quality:

97% ^*data from raw suppliers

1-[4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl]ethan-1-one 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl)ethanone

There total 10 articles about 1-(4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-acetylpiperidine (13889-98-0) + 4-fluoro-2-methoxy-1-nitrobenzene (448-19-1) → 1-(4-{3-methoxy-4-nitrophenyl}piperazine-1-yl)ethan-1-one (1116229-11-8)

Guidance literature:

In 1,4-dioxane; at 100 ℃;

Reference yield: 79.0%

2-methoxy-4-(piperazin-1-yl)nitrobenzene + acetyl chloride (75-36-5) → 1-(4-{3-methoxy-4-nitrophenyl}piperazine-1-yl)ethan-1-one (1116229-11-8)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 6h;

Reference yield: 78.0%

C11H15N3O3*C2HF3O2 + acetic anhydride (108-24-7) → 1-(4-{3-methoxy-4-nitrophenyl}piperazine-1-yl)ethan-1-one (1116229-11-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.molstruc.2017.06.107

upstream raw materials:

acetic anhydride

N-acetylpiperidine

4-fluoro-2-methoxy-1-nitrobenzene

5-fluoro-2-nitrophenol

Downstream raw materials:

1-(4-{4-amino-3-methoxyphenyl}piperazine-1-yl)ethan-1-one

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