Methyl 1-Cbz-azetidine-3-carboxylate

Base Information

• Chemical Name: Methyl 1-Cbz-azetidine-3-carboxylate
• CAS No.: 757239-60-4
• Molecular Formula: C13H15NO4
• Molecular Weight: 249.266
• Hs Code.: 2933990090
• Mol file: 757239-60-4.mol

Synonyms:1-Cbz-azetidine-3-carboxylic acid methyl ester; Methyl 1-Cbz-azetidine-3-carboxylate; 1-benzyl 3-methyl azetidine-1,3-dicarboxylate

Chemical Property of Methyl 1-Cbz-azetidine-3-carboxylate

Chemical Property:

• Boiling Point: 359.3±42.0 °C(Predicted)
• PKA: -3.02±0.40(Predicted)
• PSA: 55.84000
• Density: 1.259±0.06 g/cm3(Predicted)
• LogP: 1.36590
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1-Benzyl3-MethylAzetidine-1,3-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1-Cbz-azetidine-3-carboxylate

There total 1 articles about Methyl 1-Cbz-azetidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 3-azetidinecarboxylate hydrochloride (100202-39-9) + benzyl chloroformate (501-53-1,94274-21-2) → O1-benzyl-O3-methylazetidine-1,3-dicarboxylate (757239-60-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 18h;

Reference yield: 100.0%

O1-benzyl-O3-methylazetidine-1,3-dicarboxylate (757239-60-4) → 1-benzyloxycarbonyl-3-azetidinecarboxylic acid (97628-92-7)

Guidance literature:

With methanol; sodium hydroxide; at 20 ℃; for 3h;

Reference yield: 85.0%

O1-benzyl-O3-methylazetidine-1,3-dicarboxylate (757239-60-4) + methyl iodide (74-88-4) → 1-benzyl 3-methyl 3-methylazetidine-1,3-dicarboxylate (912444-78-1)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at -70 - -20 ℃; for 3h;

upstream raw materials:

methyl 3-azetidinecarboxylate hydrochloride

benzyl chloroformate

Downstream raw materials:

1-benzyl 3-methyl 3-methylazetidine-1,3-dicarboxylate

1-benzyl 3-methyl 3-(2-{[tert-butyl(dimethyl)silyl]oxy}-1-hydroxyethyl)azetidine-1,3-dicarboxylate

O₁-benzyl-O₃-methyl-3-phenylazetidine-1,3-dicarboxylate

1-((benzyloxy)carbonyl)-3-phenylazetidine-3-carboxylic acid

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