Technology Process of 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, 6-methyl-
There total 8 articles about 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, 6-methyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester;
With
methanol; sodium hydroxide; water;
at 70 ℃;
for 2h;
With
hydrogenchloride;
In
water;
pH=2;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 96 h / 130 °C
1.2: 85 °C
2.1: sulfuric acid / 1 h / 100 °C
2.2: 5 h
3.1: thionyl chloride / 8 h / 0 °C / Heating / reflux
4.1: sodium periodate; iodine / N,N-dimethyl-formamide / 48 h / 60 °C
5.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 5 h / 20 °C
6.1: pyridine / dichloromethane / 7 h / 0 - 20 °C
7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 70 °C
8.1: methanol; sodium hydroxide; water / 2 h / 70 °C
8.2: pH 2
With
pyridine; methanol; sodium hydroxide; sodium periodate; copper(l) iodide; thionyl chloride; sulfuric acid; tetrabutyl ammonium fluoride; water; iodine; triethylamine;
bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium periodate; iodine / N,N-dimethyl-formamide / 48 h / 60 °C
2.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 5 h / 20 °C
3.1: pyridine / dichloromethane / 7 h / 0 - 20 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 70 °C
5.1: methanol; sodium hydroxide; water / 2 h / 70 °C
5.2: pH 2
With
pyridine; methanol; sodium hydroxide; sodium periodate; copper(l) iodide; tetrabutyl ammonium fluoride; water; iodine; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
