6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester

Base Information

Chemical Name:6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester
CAS No.:872355-54-9
Molecular Formula:C₁₀H₁₀N₂O₂
Molecular Weight:190.202
Hs Code.:2933990090
Mol file:872355-54-9.mol

Synonyms:1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid,6-methyl-,methyl ester;6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester;

Suppliers and Price of 6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate 95+%
1g
$ 432.00

Chemenu
methyl6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate 95%
1g
$ 408.00

American Custom Chemicals Corporation
METHYL-6-METHYL-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLATE 95.00%
5MG
$ 505.11

Alichem
Methyl6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate
1g
$ 387.20

Total 9 raw suppliers

Chemical Property of 6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester

Chemical Property:

PSA：54.98000
LogP:1.65790

Purity/Quality:

97% ^*data from raw suppliers

Methyl6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester

There total 7 articles about 6-Methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 680208-87-1
6-acetylamino-2-methyl-5-trimethylsilanylethynyl-nicotinic acid methyl ester

: 872355-54-9
6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 70 ℃; for 4h;

Reference yield:

: 42753-71-9
5-bromo-6-methyl-pyridin-2-ylamine

: 872355-54-9
6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 96 h / 130 °C

1.2: 85 °C

2.1: sulfuric acid / 1 h / 100 °C

2.2: 5 h

3.1: thionyl chloride / 8 h / 0 °C / Heating / reflux

4.1: sodium periodate; iodine / N,N-dimethyl-formamide / 48 h / 60 °C

5.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 5 h / 20 °C

6.1: pyridine / dichloromethane / 7 h / 0 - 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 70 °C

With pyridine; sodium periodate; copper(l) iodide; thionyl chloride; sulfuric acid; tetrabutyl ammonium fluoride; iodine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 872355-52-7
methyl 6-amino-2-methylpyridine-3-carboxylate

: 872355-54-9
6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium periodate; iodine / N,N-dimethyl-formamide / 48 h / 60 °C

2: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 5 h / 20 °C

3: pyridine / dichloromethane / 7 h / 0 - 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 70 °C

With pyridine; sodium periodate; copper(l) iodide; tetrabutyl ammonium fluoride; iodine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;