METHYL 6-AMINO-2-METHYLNICOTINATE

Base Information

• Chemical Name: METHYL 6-AMINO-2-METHYLNICOTINATE
• CAS No.: 872355-52-7
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2933399090

Synonyms:METHYL 6-AMINO-2-METHYLNICOTINATE

Chemical Property of METHYL 6-AMINO-2-METHYLNICOTINATE

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 293.235°C at 760 mmHg
• Flash Point: 131.144°C
• PSA: 65.94000
• Density: 1.195g/cm³
• LogP: 0.68890
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

Methyl6-amino-2-methylnicotinate ^*data from reagent suppliers

Safty Information:

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Technology Process of METHYL 6-AMINO-2-METHYLNICOTINATE

There total 4 articles about METHYL 6-AMINO-2-METHYLNICOTINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methanol (67-56-1) + 6-amino-2-methylpyridine-3-carboxylic acid? (680208-82-6) → methyl 6-amino-2-methylpyridine-3-carboxylate (872355-52-7)

Guidance literature:

With thionyl chloride; at 80 ℃; for 15h;

DOI:10.1016/j.bmc.2021.116514

Reference yield:

methanol (67-56-1) + 6-amino-2-methylpyridine-3-carboxylic acid? (680208-82-6) + ethanol (64-17-5) → methyl 6-amino-2-methylpyridine-3-carboxylate (872355-52-7) + ethyl 6-amino-2-methylpyridine-3-carboxylate (1094346-14-1)

Guidance literature:

6-amino-2-methylpyridine-3-carboxylic acid?; ethanol; With thionyl chloride; at 0 - 70 ℃; for 18h;

methanol; at 20 - 70 ℃; for 16h;

Reference yield:

5-bromo-6-methyl-pyridin-2-ylamine (42753-71-9) → methyl 6-amino-2-methylpyridine-3-carboxylate (872355-52-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 96 h / 130 °C

1.2: 85 °C

2.1: sulfuric acid / 1 h / 100 °C

2.2: 5 h

3.1: thionyl chloride / 8 h / 0 °C / Heating / reflux

With thionyl chloride; sulfuric acid; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide;

upstream raw materials:

methanol

6-amino-2-methylpyridine-3-carboxylic acid?

ethanol

5-bromo-6-methyl-pyridin-2-ylamine

Downstream raw materials:

ethyl 6-{[5-({(1R,2S)-2-[(tert-butoxycarbonyl)amino]cyclohexyl}amino)-2-cyanopyridin-3-yl]amino}-2-methylpyridine-3-carboxylate

methyl 6-{[5-({(1R,2S)-2-[(tert-butoxycarbonyl)amino]cyclohexyl}amino)-2-cyanopyridin-3-yl]amino}-2-methylpyridine-3-carboxylate

tert-butyl {(1S,2R)-2-[(6-carbamoyl-5-{[5-(dimethylcarbamoyl)-6-methylpyridin-2-yl]amino}pyridin-3-yl)amino]cyclohexyl}carbamate

5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-{[5-(dimethylcarbamoyl)-6-methylpyridin-2-yl]amino}pyridine-2-carboxamide

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