6-Chloro-5-methoxy-nicotinic acid methyl ester

Base Information

• Chemical Name: 6-Chloro-5-methoxy-nicotinic acid methyl ester
• CAS No.: 915107-31-2
• Molecular Formula: C8H8ClNO3
• Molecular Weight: 201.609
• Hs Code.: 2933399090
• Mol file: 915107-31-2.mol

Synonyms:6-Chloro-5-methoxypyridine-3-carboxylic acid methyl ester;methyl 6-chloro-5-methoxynicotinate;6-chloro-5-methoxynicotinic acid methyl ester;

Chemical Property of 6-Chloro-5-methoxy-nicotinic acid methyl ester

Chemical Property:

• PSA: 48.42000
• LogP: 1.53020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

Methyl6-chloro-5-methoxynicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Chloro-5-methoxy-nicotinic acid methyl ester

There total 2 articles about 6-Chloro-5-methoxy-nicotinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 6-chloro-5-hydroxypyridine-3-carboxylate (915107-30-1) + methyl iodide (74-88-4) → methyl 6-chloro-5-methoxypyridine-3-carboxylate (915107-31-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

methyl 5-hydroxy-3-pyridinecarboxylate (30766-22-4) → methyl 6-chloro-5-methoxypyridine-3-carboxylate (915107-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 18 h / 80 °C

2: potassium carbonate / acetone / 5 h / 50 °C

With N-chloro-succinimide; potassium carbonate; In N,N-dimethyl-formamide; acetone;

Reference yield: 84.0%

methyl 6-chloro-5-methoxypyridine-3-carboxylate (915107-31-2) → (6-chloro-5-methoxypyridin-3-yl)methanol (915107-47-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

upstream raw materials:

methyl 6-chloro-5-hydroxypyridine-3-carboxylate

methyl iodide

methyl 5-hydroxy-3-pyridinecarboxylate

Downstream raw materials:

6-chloro-5-methoxynicotinic acid

(6-chloro-5-methoxypyridin-3-yl)methanol

5-hydroxy imidacloprid

Refernces

• 1、 -. "TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF". Paragraph 0493; 0495. . Retrieved 2017/01/23.
• 2、 -. "BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 065". Page/Page column 66. . Retrieved 2009/05/28.