1,2,3,4-Tetrahydro-6,7-dimethoxy-2-(phenylmethyl)isoquinoline

Base Information

• Chemical Name: 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-(phenylmethyl)isoquinoline
• CAS No.: 31756-14-6
• Molecular Formula: C18H21NO2
• Molecular Weight: 283.37
• Hs Code.: 2933499090
• Mol file: 31756-14-6.mol

Synonyms:1,2,3,4-Tetrahydro-6,7-dimethoxy-2-(phenylmethyl)isoquinoline

Chemical Property of 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-(phenylmethyl)isoquinoline

Chemical Property:

• Melting Point: 85-87℃
• PSA: 21.70000
• Density: 1.117
• LogP: 3.20000

Purity/Quality:

97% ^*data from raw suppliers

2-Benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-(phenylmethyl)isoquinoline

There total 13 articles about 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-(phenylmethyl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2-ium hydrobromide (5096-82-2) → 2-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (31756-14-6)

Guidance literature:

With tri-n-butyl-tin hydride; In methanol; for 5h; Ambient temperature;

DOI:10.1055/s-1985-31434

Reference yield: 77.0%

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (1745-07-9) + benzyl bromide (100-39-0) → 2-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (31756-14-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1002/jhet.252

Reference yield: 63.0%

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride (2328-12-3) + benzyl bromide (100-39-0) → 2-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (31756-14-6)

Guidance literature:

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride; With triethylamine; In ethanol; at 20 ℃; for 1h; Inert atmosphere;

benzyl bromide; In ethanol; at 20 ℃; for 3.5h; Inert atmosphere;

DOI:10.1002/ejoc.201001120

upstream raw materials:

formaldehyd

N-benzyl-2-(3,4-dimethoxyphenyl)ethylamine

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

benzyl bromide

Downstream raw materials:

2-benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide

2-benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol

2-benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-1(2H)-one