2-benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide

Base Information

• Chemical Name: 2-benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide
• CAS No.: 900784-81-8
• Molecular Formula: BrH*C₁₆H₁₇NO₂
• Molecular Weight: 336.228
• Mol file: 900784-81-8.mol

Synonyms:2-benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide

Chemical Property of 2-benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide

There total 3 articles about 2-benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (31756-14-6) → 2-benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide (900784-81-8)

Guidance literature:

With hydrogen bromide; In water; at 20 - 120 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201001120

Reference yield:

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride (2328-12-3) → 2-benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide (900784-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / ethanol / 1 h / 20 °C / Inert atmosphere

1.2: 3.5 h / 20 °C / Inert atmosphere

2.1: hydrogen bromide / water / 20 - 120 °C / Inert atmosphere

With hydrogen bromide; triethylamine; In ethanol; water;

DOI:10.1002/ejoc.201001120

Reference yield:

benzyl bromide (100-39-0) → 2-benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide (900784-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / ethanol / 1 h / 20 °C / Inert atmosphere

1.2: 3.5 h / 20 °C / Inert atmosphere

2.1: hydrogen bromide / water / 20 - 120 °C / Inert atmosphere

With hydrogen bromide; triethylamine; In ethanol; water;

DOI:10.1002/ejoc.201001120

upstream raw materials:

2-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride

benzyl bromide

Downstream raw materials:

2-benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol