tert-Butyl 4-(2-oxo-4-phenyl-2,3-dihydro-1H-imidazol-1-yl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-Butyl 4-(2-oxo-4-phenyl-2,3-dihydro-1H-imidazol-1-yl)piperidine-1-carboxylate
• CAS No.: 205058-11-3
• Molecular Formula: C19H25N3O3
• Molecular Weight: 343.426
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID10470093
• Wikidata: Q82298074
• Mol file: 205058-11-3.mol

Synonyms:205058-11-3;tert-Butyl 4-(2-oxo-4-phenyl-2,3-dihydro-1H-imidazol-1-yl)piperidine-1-carboxylate;tert-butyl 4-(2-oxo-5-phenyl-1H-imidazol-3-yl)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-(2,3-dihydro-2-oxo-4-phenyl-1H-imidazol-1-yl)-, 1,1-dimethylethyl ester;SCHEMBL2104155;DTXSID10470093;YRSWXNHAXXQSBX-UHFFFAOYSA-N;AKOS016003013;DS-17450;O12126;A912415;tert-Butyl 4-(1,2-dihydro-2-oxo-5-phenylimidazol-3-yl)piperidine-1-carboxylate

Chemical Property of tert-Butyl 4-(2-oxo-4-phenyl-2,3-dihydro-1H-imidazol-1-yl)piperidine-1-carboxylate

Chemical Property:

• PKA: 11.49±0.70(Predicted)
• PSA: 67.33000
• Density: 1.200±0.06 g/cm3(Predicted)
• LogP: 3.35330
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 343.18959167
• Heavy Atom Count: 25
• Complexity: 539

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 4-(2-oxo-4-phenyl-2,3-dihydro-1H-imidazol-1-yl)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCC(CC1)N2C=C(NC2=O)C3=CC=CC=C3

Technology Process of tert-Butyl 4-(2-oxo-4-phenyl-2,3-dihydro-1H-imidazol-1-yl)piperidine-1-carboxylate

There total 5 articles about tert-Butyl 4-(2-oxo-4-phenyl-2,3-dihydro-1H-imidazol-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-(1,1-dimethylethoxycarbonyl)-4-piperidinammonium hydrogencarbonate + sodium isocyanate (917-61-3) + α-bromoacetophenone (70-11-1) → 4-(1,3-dihydro-2(2H)-oxo-4-phenyl-imidazol-1-yl)-1-(1,1-dimethylethoxycarbonyl)piperidine (205058-11-3)

Guidance literature:

1-(1,1-dimethylethoxycarbonyl)-4-piperidinammonium hydrogencarbonate; α-bromoacetophenone; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 7h;

sodium isocyanate; With acetic acid; In dichloromethane; cooling;

DOI:10.1021/jm0490641

Reference yield: 47.0%

sodium isocyanate (917-61-3) + 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → 4-(1,3-dihydro-2(2H)-oxo-4-phenyl-imidazol-1-yl)-1-(1,1-dimethylethoxycarbonyl)piperidine (205058-11-3)

Guidance literature:

1-(tert-butoxycarbonyl)-4-aminopiperidine; α-bromoacetophenone; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 17h;

sodium isocyanate; With acetic acid; In dichloromethane; at 0 - 20 ℃; for 16h; pH=4;

Reference yield:

2-bromophenyl methyl ketone (2142-69-0) + sodium isocyanate (917-61-3) + 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → 4-(1,3-dihydro-2(2H)-oxo-4-phenyl-imidazol-1-yl)-1-(1,1-dimethylethoxycarbonyl)piperidine (205058-11-3)

Guidance literature:

2-bromophenyl methyl ketone; 1-(tert-butoxycarbonyl)-4-aminopiperidine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

sodium isocyanate; With acetic acid; In dichloromethane;

upstream raw materials:

sodium isocyanate

α-bromoacetophenone

1-(tert-butoxycarbonyl)-4-aminopiperidine

2-bromophenyl methyl ketone

Downstream raw materials:

4-(1,3-dihydro-4-phenyl-2(2H)-oxoimidazol-1-yl)piperidine

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