5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 723286-79-1
• Molecular Formula: C10H16N4O2
• Molecular Weight: 224.263
• Hs Code.: 2933990090
• Mol file: 723286-79-1.mol

Synonyms:TERT-BUTYL 5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE;tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate ,99%;

Chemical Property of 5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Boiling Point: 378.4±52.0 °C(Predicted)
• PKA: 2.87±0.20(Predicted)
• PSA: 60.25000
• Density: 1.28±0.1 g/cm3(Predicted)
• LogP: 0.96670
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 4 articles about 5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

di-tert-butyl dicarbonate (24424-99-5) + 5,6,7,8-tetrahydro-(1,2,4)triazolo(4,3-a)-pyrazine hydrochloride (837430-14-5) → tert-butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate (723286-79-1)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃;

Reference yield: 22.0%

8-chloro-[1,2,4]triazolo[4,3-a]pyrazine (68774-77-6) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate (723286-79-1)

Guidance literature:

8-chloro-[1,2,4]triazolo[4,3-a]pyrazine; With platinum(IV) oxide; palladium 10% on activated carbon; hydrogen; In methanol; for 34h; under 2585.81 Torr;

di-tert-butyl dicarbonate; With N-ethyl-N,N-diisopropylamine; In methanol; at 20 ℃; for 3h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (345311-09-3) → tert-butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate (723286-79-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

di-tert-butyl dicarbonate

5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

5,6,7,8-tetrahydro-(1,2,4)triazolo(4,3-a)-pyrazine hydrochloride

8-chloro-[1,2,4]triazolo[4,3-a]pyrazine

Downstream raw materials:

C₁₁H₁₆N₄O₃

3-bromo-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

7-(tert-butoxycarbonyl)-3-methoxy-5,6,7,8-tetrahydro[1,2,4]triazolo[3,4-a]pyrazine

C₂₂H₂₈N₆O*ClH

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