tert-butyl 3-methoxy-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate

Base Information

Chemical Name:tert-butyl 3-methoxy-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
CAS No.:723286-81-5
Molecular Formula:C₁₁H₁₈N₄O₃
Molecular Weight:254.289
Hs Code.:2933990090
Mol file:723286-81-5.mol

Synonyms:tert-Butyl 5,6-dihydro-3-methoxy-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate ,98%;

Suppliers and Price of tert-butyl 3-methoxy-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 8 raw suppliers

Chemical Property of tert-butyl 3-methoxy-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate

Chemical Property:

Vapor Pressure:1.22E-06mmHg at 25°C
Boiling Point:401°C at 760 mmHg
PKA:2.79±0.20(Predicted)
Flash Point:196.3°C
PSA：69.48000
Density:1.29g/cm³
LogP:0.97530

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl 3-methoxy-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate

There total 4 articles about tert-butyl 3-methoxy-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 723286-80-4
3-bromo-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester

: 124-41-4
sodium methylate

: 723286-81-5
7-(tert-butoxycarbonyl)-3-methoxy-5,6,7,8-tetrahydro[1,2,4]triazolo[3,4-a]pyrazine

Guidance literature:: In methanol; at 65 ℃; for 24h;

Reference yield:

: 274-82-8
[1,2,4]triazolo[4,3-a]pyrazine

: 723286-81-5
7-(tert-butoxycarbonyl)-3-methoxy-5,6,7,8-tetrahydro[1,2,4]triazolo[3,4-a]pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C / 760.05 Torr

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

3: N-Bromosuccinimide; sodium hydrogencarbonate / chloroform / 16 h / 0 - 20 °C

4: methanol / 24 h / 65 °C

With N-Bromosuccinimide; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dichloromethane; chloroform;

Reference yield:

: 723286-79-1
tert-butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate

: 723286-81-5
7-(tert-butoxycarbonyl)-3-methoxy-5,6,7,8-tetrahydro[1,2,4]triazolo[3,4-a]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; sodium hydrogencarbonate / chloroform / 16 h / 0 - 20 °C

2: methanol / 24 h / 65 °C

With N-Bromosuccinimide; sodium hydrogencarbonate; In methanol; chloroform;