methyl 3-amino-2-fluorobenzoate

Base Information

• Chemical Name: methyl 3-amino-2-fluorobenzoate
• CAS No.: 1195768-18-3
• Molecular Formula: C8H8FNO2
• Molecular Weight: 169.155
• Hs Code.: 2922499990
• Mol file: 1195768-18-3.mol

Synonyms:Ethyl 3-amino-2-fluorobenzoate;

Chemical Property of methyl 3-amino-2-fluorobenzoate

Chemical Property:

• Refractive Index: 1.5570 to 1.5610
• Boiling Point: 295.978 °C at 760 mmHg
• PKA: 2.06±0.10(Predicted)
• Flash Point: 132.803 °C
• PSA: 52.32000
• Density: 1.219 g/cm³
• LogP: 1.77570
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl 3-Amino-2-fluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 3-amino-2-fluorobenzoate is a useful chemical compound.

Technology Process of methyl 3-amino-2-fluorobenzoate

There total 11 articles about methyl 3-amino-2-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-fluoro-3-nitrobenzoic acid methyl ester (946126-94-9) → 3-amino-2-fluorobenzoic acid methyl ester (1195768-18-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol;

DOI:10.1016/j.ejmech.2020.112963

Reference yield: 99.0%

→ 3-amino-2-fluorobenzoic acid methyl ester (1195768-18-3)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃;

Reference yield: 94.1%

methyl 6-chloro-2-fluoro-3-nitrobenzoate → 3-amino-2-fluorobenzoic acid methyl ester (1195768-18-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 50 - 55 ℃; under 4500.45 - 5250.53 Torr; Temperature; Pressure; Autoclave;

upstream raw materials:

2-fluoro-3-nitrobenzoic acid methyl ester

methyl 3-((tert-butoxycarbonyl)amino)-2-fluorobenzoate

2-fluoro-3-nitro-benzoic acid

3-bromo-2-fluorobenzoic acid

Downstream raw materials:

3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester

methyl-3-[(allyloxy)carbonyl]amino-2-fluorobenzoate

3-(2,6-difluorobenzenesulfonamido)-2-fluorobenzoic acid methyl ester

methyl 2-fluoro-3-(2-fluoro-3-nitrobenzamido)benzoate

Refernces

• 1、 -. "ALTERNATE PROCESSES FOR THE PREPARATION OF OMECAMTIV MECARBIL". . . Retrieved 2021/04/17.
• 2、 -. "PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH". Page/Page column 32; 53. . Retrieved 2018/08/12.