Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate

Base Information

Chemical Name:Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate
CAS No.:1195768-19-4
Molecular Formula:C14H10F3NO4S
Molecular Weight:345.299
Hs Code.:
Mol file:1195768-19-4.mol

Synonyms:Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate;Methyl 3-{[(2,6-difluorophenyl)sulfonyl]aMino}-2-fluorobenzoate;Methyl 3-(2,6-difluorophenylsulfonaMido)-2-fluorobenzoate

Suppliers and Price of Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate 95+%
5g
$ 743.00

Crysdot
Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate 95+%
1g
$ 248.00

Alichem
Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
5g
$ 787.50

AK Scientific
Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
250mg
$ 123.00

Total 54 raw suppliers

Chemical Property of Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate

Chemical Property:

Boiling Point:445.4±55.0 °C(Predicted)
PKA:6.68±0.10(Predicted)
PSA：80.85000
Density:1.507±0.06 g/cm3(Predicted)
LogP:3.84510
Storage Temp.:Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate

There total 8 articles about Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1195768-18-3
3-amino-2-fluorobenzoic acid methyl ester

: 60230-36-6
2,6-difluorobenzene-1-sulfonyl chloride

: 1195768-19-4
3-(2,6-difluorobenzenesulfonamido)-2-fluorobenzoic acid methyl ester

Guidance literature:: With pyridine; In dichloromethane; at 15 - 25 ℃;

Reference yield:

: 206551-41-9
2-fluoro-3-bromobenzoic acid methyl ester

: 1195768-19-4
3-(2,6-difluorobenzenesulfonamido)-2-fluorobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 90 °C / Sealed tube; Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: pyridine / dichloromethane / 20 °C

With pyridine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ml4000063

Reference yield:

3-bromo-2-fluorobenzoic acid: 161957-56-8
3-bromo-2-fluorobenzoic acid

: 1195768-19-4
3-(2,6-difluorobenzenesulfonamido)-2-fluorobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 1 h / Reflux

2: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 90 °C / Sealed tube; Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: pyridine / dichloromethane / 20 °C

With pyridine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sulfuric acid; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ml4000063