3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester

Base Information

Chemical Name:3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester
CAS No.:1195768-24-1
Molecular Formula:C₁₄H₁₀F₃NO₄S
Molecular Weight:345.299
Hs Code.:

Synonyms:3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester

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Chemical Property of 3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester

Chemical Property:

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Technology Process of 3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester

There total 8 articles about 3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1195768-18-3
3-amino-2-fluorobenzoic acid methyl ester

: 26120-86-5
2,5-difluorobenzenesulfonyl chloride

: 1195768-24-1
3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester

Guidance literature:: With pyridine; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 317-46-4
2-fluoro-3-nitro-benzoic acid

: 1195768-24-1
3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / 5%-palladium/activated carbon / methanol / 45 h / 20 °C

2: sulfuric acid / 44 h / Reflux

3: pyridine / dichloromethane / 20 °C

With pyridine; sulfuric acid; hydrogen; 5%-palladium/activated carbon; In methanol; dichloromethane;

Reference yield:

: 206551-41-9
2-fluoro-3-bromobenzoic acid methyl ester

: 1195768-24-1
3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: pyridine / dmap / dichloromethane / 0 - 20 °C

With pyridine; caesium carbonate; trifluoroacetic acid; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; toluene;