4-(4-BROMO-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 4-(4-BROMO-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID
• CAS No.: 886366-94-5
• Molecular Formula: C₁₀H₆BrNO₂S
• Molecular Weight: 284.133
• Hs Code.: 2934100090
• Mol file: 886366-94-5.mol

Synonyms:4-(4-Bromophenyl)thiazole-2-carboxylicAcid;4-(4-BROMOPHENYL)-2-THIAZOLECARBOXYLIC ACID;

Chemical Property of 4-(4-BROMO-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID

Chemical Property:

• Boiling Point: 475.1±37.0 °C(Predicted)
• PKA: 2.77±0.10(Predicted)
• PSA: 78.43000
• Density: 1.710±0.06 g/cm3(Predicted)
• LogP: 3.27080

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Bromophenyl)thiazole-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-BROMO-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID

There total 2 articles about 4-(4-BROMO-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

para-bromoacetophenone (99-90-1) → 4-(4-Bromo-phenyl)-thiazole-2-carboxylic acid (886366-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 0.5 h / Heating

2: KOH, water / 0.08 h / Heating

With potassium hydroxide; water; In ethanol;

DOI:10.1039/P19810002335

Reference yield:

4-p-Brom-phenyl-2-carbethoxy-thiazol (53101-02-3) → 4-(4-Bromo-phenyl)-thiazole-2-carboxylic acid (886366-94-5)

Guidance literature:

With potassium hydroxide; water; for 0.0833333h; Heating;

DOI:10.1039/P19810002335

Reference yield:

methanol (67-56-1) + 4-(4-Bromo-phenyl)-thiazole-2-carboxylic acid (886366-94-5) → 4-(4-Bromo-phenyl)-thiazole-2-carboxylic acid methyl ester (79247-93-1)

Guidance literature:

With sulfuric acid; at 20 ℃; for 240h;

DOI:10.1039/P19810002335

upstream raw materials:

4-p-Brom-phenyl-2-carbethoxy-thiazol

para-bromoacetophenone

Downstream raw materials:

4-(4-Bromo-phenyl)-thiazole-2-carboxylic acid methyl ester