Technology Process of 5-Ethynyl-2-methoxybenzonitrile
There total 1 articles about 5-Ethynyl-2-methoxybenzonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
dichloromethane;
for 2h;
- Guidance literature:
-
(trifluoromethyl)trimethylsilane;
With
copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; oxygen; potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1.5h;
5-ethynyl-2-methoxybenzonitrile;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 24h;
DOI:10.1002/adsc.201700122
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; potassium carbonate; oxygen / N,N-dimethyl-formamide / 1.5 h / 20 °C
1.2: 24 h / 0 - 20 °C
2.1: copper diacetate / methanol / 3 h / 28 °C / Inert atmosphere
3.1: MoCl2O2(dmf)2; triphenylphosphine / toluene / 3 h / -78 - 80 °C / Inert atmosphere
With
copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; MoCl2O2(dmf)2; oxygen; copper diacetate; potassium carbonate; triphenylphosphine;
In
methanol; N,N-dimethyl-formamide; toluene;
3.1: |Cadogan-Cameron Wood Cyclization;
DOI:10.1002/adsc.201700122
