ethyl 4-hydroxy-1-isopentyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 4-hydroxy-1-isopentyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate
• CAS No.: 850814-34-5
• Molecular Formula: C₁₆H₂₀N₂O₄
• Molecular Weight: 304.346
• Hs Code.: 2933990090
• Mol file: 850814-34-5.mol

Synonyms:Ethyl 4-hydroxy-1-isopentyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate;ethyl 4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate;

Chemical Property of ethyl 4-hydroxy-1-isopentyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

Chemical Property:

• PSA: 81.42000
• LogP: 2.32490

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 4-hydroxy-1-isopentyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate 95% ^*data from reagent suppliers

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Technology Process of ethyl 4-hydroxy-1-isopentyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

There total 2 articles about ethyl 4-hydroxy-1-isopentyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

ethyl chlorocarbonylacetate (36239-09-5) + Ethyl 2-[(3-methylbutyl)amino]-3-pyridinecarboxylate (691360-28-8) → ethyl 4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate (850814-34-5)

Guidance literature:

ethyl chlorocarbonylacetate; Ethyl 2-[(3-methylbutyl)amino]-3-pyridinecarboxylate; In dichloromethane; at 20 ℃; for 1h;

With triethylamine; In dichloromethane;

ethyl chlorocarbonylacetate; With hydrogenchloride; sodium ethanolate; sodium hydrogencarbonate; more than 3 stages;

Reference yield:

diethyl malonate (105-53-3) + 1-(3-methylbutyl)-2H-pyrido[2,3-d][1,3]oxazine-2,4(1H)-dione (565448-79-5) → ethyl 4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate (850814-34-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl acetamide; at 120 ℃; for 2h;

DOI:10.1016/j.bmcl.2005.01.071

upstream raw materials:

diethyl malonate

1-(3-methylbutyl)-2H-pyrido[2,3-d][1,3]oxazine-2,4(1H)-dione

ethyl chlorocarbonylacetate

Ethyl 2-[(3-methylbutyl)amino]-3-pyridinecarboxylate

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