1-(5-bromopyridin-2-yl)-2,2,2-trifluoroethanol

Base Information

• Chemical Name: 1-(5-bromopyridin-2-yl)-2,2,2-trifluoroethanol
• CAS No.: 917397-92-3
• Molecular Formula: C₇H₅BrF₃NO
• Molecular Weight: 256.022
• Mol file: 917397-92-3.mol

Synonyms:1-(5-bromopyridin-2-yl)-2,2,2-trifluoroethanol

Chemical Property of 1-(5-bromopyridin-2-yl)-2,2,2-trifluoroethanol

Chemical Property:

• PSA: 33.12000
• LogP: 2.43980
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(5-Bromopyridin-2-yl)-2,2,2-trifluoroethan-1-ol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-bromopyridin-2-yl)-2,2,2-trifluoroethanol

There total 3 articles about 1-(5-bromopyridin-2-yl)-2,2,2-trifluoroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-bromo-pyridine-2-carbaldehyde (31181-90-5) + (trifluoromethyl)trimethylsilane (81290-20-2) → 1-(5-bromo-pyridin-2-yl)-2,2,2-trifluoroethanol (917397-92-3)

Guidance literature:

5-bromo-pyridine-2-carbaldehyde; (trifluoromethyl)trimethylsilane; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

With tetrabutyl ammonium fluoride; In N,N-dimethyl-formamide; for 4h;

DOI:10.1016/j.tetlet.2013.06.045

Reference yield:

1-(5-bromopyridin-2-yl)-2,2,2-trifluoroethanone (886364-50-7) → 1-(5-bromo-pyridin-2-yl)-2,2,2-trifluoroethanol (917397-92-3)

Guidance literature:

1-(5-bromopyridin-2-yl)-2,2,2-trifluoroethanone; With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h;

With acetic acid; In methanol;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

→ 1-(5-bromo-pyridin-2-yl)-2,2,2-trifluoroethanol (917397-92-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; for 1h;

upstream raw materials:

1-(5-bromopyridin-2-yl)-2,2,2-trifluoroethanone

5-bromo-pyridine-2-carbaldehyde

(trifluoromethyl)trimethylsilane

Downstream raw materials:

1-(5-bromopyridin-2-yl)-2,2,2-trifluoroethanone