N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine

Base Information

Chemical Name:N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine
CAS No.:267243-68-5
Molecular Formula:C21H23ClFN5O2
Molecular Weight:431.897
Hs Code.:2934999090
DSSTox Substance ID:DTXSID20436105
Wikidata:Q82251313
Mol file:267243-68-5.mol

Synonyms:267243-68-5;N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine;4-N-(3-chloro-4-fluorophenyl)-7-(3-morpholin-4-ylpropoxy)quinazoline-4,6-diamine;N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-quinazoline-4,6-diamine;intermediate 2 of Canertinib;SCHEMBL2963866;AMY9172;DTXSID20436105;HBUGOFLVIGUDIA-UHFFFAOYSA-N;BCP30233;AKOS016000568;DS-5452;AC-26219;CS-0320572;FT-0696496;C74380;(3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-aminoquinazolin-4-yl]-amine;(3-chloro-4-fluorophenyl)-[7-(3-morpholin-4-yl-propoxy)-6-aminoquinazolin4-yl]-amine;N*4*-(3-Chloro-4-fluoro-phenyl)-7-(3-morpholin-4-yl-propoxy)-quinazoline-4,6-diamine

Suppliers and Price of N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine 95+%
100 mg
$ 545.00

Matrix Scientific
N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-quinazoline-4,6-diamine 95+%
1g
$ 1647.00

Matrix Scientific
N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-quinazoline-4,6-diamine 95+%
250mg
$ 742.00

Crysdot
N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine 95+%
250mg
$ 129.00

Crysdot
N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine 95+%
100mg
$ 81.00

Crysdot
N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine 95+%
1g
$ 322.00

Chemenu
N4-(3-chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine 95%
1g
$ 304.00

American Custom Chemicals Corporation
N4-(3-CHLORO-4-FLUOROPHENYL)-7-(3-MORPHOLINOPROPOXY)QUINAZOLINE-4,6-DIAMINE 95.00%
100MG
$ 414.75

Alichem
N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine
1g
$ 325.00

Total 36 raw suppliers

Chemical Property of N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine

Chemical Property:

Boiling Point:613.5±55.0 °C(Predicted)
PKA:7.03±0.10(Predicted)
PSA：85.53000
Density:1.366±0.06 g/cm3(Predicted)
LogP:4.44130
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:431.1524308
Heavy Atom Count:30
Complexity:530

Purity/Quality:

97% ^*data from raw suppliers

N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCN1CCCOC2=C(C=C3C(=C2)N=CN=C3NC4=CC(=C(C=C4)F)Cl)N

Technology Process of N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine

There total 11 articles about N4-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)quinazoline-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

: 267243-64-1
(3-chloro-4-fluorophenyl)-[7-(3-morpholino-4-yl-propoxy)-6-nitroquinazolin-4-yl]-amine

: 267243-68-5
(3-CHLORO-4-FLUOROPHENYL)-[7-(3-MORPHOLIN-4-YL-PROPOXY)-6-AMINO-QUINAZOLINE-4-YL]-AMINE

Guidance literature:: aluminum nickel; In tetrahydrofuran;

Reference yield:

: 4441-30-9
3-morpholin-4-ylpropan-1-ol

: 367-21-5
3-chloro-4-fluorophenylamine

: 865-47-4
potassium tert-butylate

: 162012-69-3
7-fluoro-6-nitro-3H-quinazolin-4-one

: 267243-68-5
(3-CHLORO-4-FLUOROPHENYL)-[7-(3-MORPHOLIN-4-YL-PROPOXY)-6-AMINO-QUINAZOLINE-4-YL]-AMINE

Guidance literature:: With hydrogenchloride; aluminum nickel; In tetrahydrofuran; thionyl chloride; ethanol; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 162012-67-1
N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

: 267243-68-5
(3-CHLORO-4-FLUOROPHENYL)-[7-(3-MORPHOLIN-4-YL-PROPOXY)-6-AMINO-QUINAZOLINE-4-YL]-AMINE

Guidance literature:: Multi-step reaction with 2 steps

1.1: Na / tetrahydrofuran / 2 h / 20 °C

1.2: 58 percent / tetrahydrofuran

2.1: 78 percent / Fe; aq. HOAc / ethanol / 0.5 h / Heating

With sodium; iron; acetic acid; In tetrahydrofuran; ethanol; 1.1: deprotonation / 1.2: Substitution / 2.1: Reduction;
DOI:10.1021/jm990482t