N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine

Base Information

Chemical Name:N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine
CAS No.:267243-64-1
Molecular Formula:C21H21ClFN5O4
Molecular Weight:461.88
Hs Code.:
DSSTox Substance ID:DTXSID00442300
Wikidata:Q82259506
Mol file:267243-64-1.mol

Synonyms:267243-64-1;N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine;N-(3-chloro-4-fluorophenyl)-7-(3-morpholin-4-ylpropoxy)-6-nitroquinazolin-4-amine;4-Quinazolinamine,N-(3-chloro-4-fluorophenyl)-7-[3-(4-morpholinyl)propoxy]-6-nitro-;C21H21ClFN5O4;SCHEMBL5675006;AMY9168;DTXSID00442300;QVZKEQDJKMFEDU-UHFFFAOYSA-N;BCP30234;propoxy)-6-nitroquinazolin-4-aMine;MFCD12032146;AKOS015917906;(3-CHLORO-4-FLUORO-PHENYL)-[7-(3-MORPHOLIN-4-YL-PROPOXY)-6-NITRO-QUINAZOLIN-4-YL]-AMINE;BS-16755;A5258;CS-0158329;FT-0687658;D82687;N-(3-chloro-4-fluorophenyl)-7-(3-Morpholino;(3-chloro-4-fluoro-phenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitroquinazolin-4yl]-amine;N-(3-chloro-4-fluorophenyl)-7-(3-Morpholino propoxy)-6-nitroquinazolin-4-aMine;N-(3-CHLORO-4-FLUOROPHENYL)-7-[3-(MORPHOLIN-4-YL)PROPOXY]-6-NITROQUINAZOLIN-4-AMINE

Suppliers and Price of N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine 95+%
1g
$ 1186.00

Chemenu
N-(3-chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine 95%
1g
$ 1118.00

Ambeed
N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine 95%
1g
$ 1152.00

Ambeed
N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine 95%
250mg
$ 442.00

Ambeed
N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine 95%
100mg
$ 253.00

Ambeed
N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine 95%
50mg
$ 193.00

Alichem
N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine
1g
$ 969.60

Total 28 raw suppliers

Chemical Property of N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.649
Boiling Point:637.065 °C at 760 mmHg
PKA:6.91±0.10(Predicted)
Flash Point:339.085 °C
PSA：105.33000
Density:1.418 g/cm³
LogP:4.70930
Storage Temp.:2-8°C(protect from light)
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:7
Exact Mass:461.1266100
Heavy Atom Count:32
Complexity:611

Purity/Quality:

97% ^*data from raw suppliers

N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCN1CCCOC2=C(C=C3C(=C2)N=CN=C3NC4=CC(=C(C=C4)F)Cl)[N+](=O)[O-]

Technology Process of N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine

There total 12 articles about N-(3-Chloro-4-fluorophenyl)-7-(3-morpholinopropoxy)-6-nitroquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.5%

: 4441-30-9
3-morpholin-4-ylpropan-1-ol

: 367-21-5
3-chloro-4-fluorophenylamine

: 162012-69-3
7-fluoro-6-nitro-3H-quinazolin-4-one

: 267243-64-1
(3-chloro-4-fluorophenyl)-[7-(3-morpholino-4-yl-propoxy)-6-nitroquinazolin-4-yl]-amine

Guidance literature:: 7-fluoro-6-nitro-3H-quinazolin-4-one; With thionyl chloride; N,N-dimethyl-formamide; for 24h; Heating / reflux;

3-morpholin-4-ylpropan-1-ol; 3-chloro-4-fluorophenylamine; In tetrahydrofuran; tert-butyl alcohol; at 10 - 20 ℃; for 24h;

With hydrogenchloride; potassium tert-butylate; more than 3 stages;