N-(pyridin-2-ylmethyl)ethanamine

Base Information

• Chemical Name: N-(pyridin-2-ylmethyl)ethanamine
• CAS No.: 51639-58-8
• Molecular Formula: C8H12N2
• Molecular Weight: 136.197
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00406028
• Mol file: 51639-58-8.mol

Synonyms:51639-58-8;N-(pyridin-2-ylmethyl)ethanamine;N-Ethyl-N-(2-pyridylmethyl)amine;N-(2-PYRIDINYLMETHYL)ETHANAMINE;ethyl(pyridin-2-ylmethyl)amine;2-Pyridinemethanamine, N-ethyl-;ethyl[(pyridin-2-yl)methyl]amine;MFCD07411568;N-Ethyl-2-pyridylmethylamine;ethyl-pyridin-2-ylmethyl-amine;SCHEMBL1040663;N-(2-pyridinylmethyl)ethylamine;DTXSID00406028;BQSUUGOCTJVJIF-UHFFFAOYSA-N;N-ethyl-N-(2-pyridylmethyl) amine;STK511427;AKOS000152850;CF-0240;SB52299;SY005911;_x000D_N-Ethyl-N-(2-pyridylmethyl)amine;CS-0151964;FT-0743746;N-(2-Pyridinylmethyl)ethanamine, AldrichCPR;A21962;EN300-102696;Z90513146

Chemical Property of N-(pyridin-2-ylmethyl)ethanamine

Chemical Property:

• Vapor Pressure: 0.335mmHg at 25°C
• Boiling Point: 199.8°C at 760 mmHg
• Flash Point: 74.7°C
• PSA: 24.92000
• Density: 0.967g/cm³
• LogP: 1.58200
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 136.100048391
• Heavy Atom Count: 10
• Complexity: 83.3

Purity/Quality:

98%Min ^*data from raw suppliers

N-Ethyl-N-(2-pyridylmethyl)amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

• Canonical SMILES: CCNCC1=CC=CC=N1

Technology Process of N-(pyridin-2-ylmethyl)ethanamine

There total 3 articles about N-(pyridin-2-ylmethyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-(Bromomethyl)pyridine (55401-97-3) + ethylamine (75-04-7,85404-22-4) → N-(pyridin-2-ylmethyl)ethanamine (51639-58-8)

Guidance literature:

In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.9b00980

Reference yield:

pyridine-2-carbaldehyde (1121-60-4) + ethylamine (75-04-7,85404-22-4) → N-(pyridin-2-ylmethyl)ethanamine (51639-58-8)

Guidance literature:

pyridine-2-carbaldehyde; ethylamine; In tetrahydrofuran; methanol; at 20 ℃; for 24h; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

Reference yield:

→ N-(pyridin-2-ylmethyl)ethanamine (51639-58-8)

Guidance literature:

entspr. Imin, NaBH4;

DOI:10.1002/mrc.1270071007

upstream raw materials:

pyridine-2-carbaldehyde

ethylamine

2-(Bromomethyl)pyridine

Downstream raw materials:

N-ethyl-N-pyridin-2-ylmethyl-2-p-tolylamino-acetamide

2-[(6-Chloro-3-methyl-benzo[d]isothiazol-5-yl)-(3,4-dimethoxy-benzenesulfonyl)-amino]-N-ethyl-N-pyridin-2-ylmethyl-acetamide

N-(2'-pyridylmethyl)-N-ethyl-4-(2,4,6-trimethyphenyl)-1phthalazinamine

Refernces

• 1、 Cheng, Hei Wun Alison,Sokias, Renee,Werry, Eryn L.,Ittner, Lars M.,Reekie, Tristan A.,Du, Jonathan,Gao, Quanqing,Hibbs, David E.,Kassiou, Michael. "First Nondiscriminating Translocator Protein Ligands Produced from a Carbazole Scaffold". supporting information. p. 8235 - 8248. Retrieved 2019/10/11.
• 2、 -. "2-Aryl Imidazo[1,2-a]Pyridine-3-Acetamide Derivatives, Preparation Methods and Uses Thereof". Paragraph 0122; 0123; 0126. . Retrieved 2013/08/15.