6-Bromo-N-methyl-4-quinolinamine

Base Information

• Chemical Name: 6-Bromo-N-methyl-4-quinolinamine
• CAS No.: 916812-31-2
• Molecular Formula: C₁₀H₉BrN₂
• Molecular Weight: 237.099
• Hs Code.: 2933499090
• Mol file: 916812-31-2.mol

Synonyms:6-Bromo-N-methylquinolin-4-amine

Chemical Property of 6-Bromo-N-methyl-4-quinolinamine

Chemical Property:

• Boiling Point: 362℃
• PKA: 8.68±0.16(Predicted)
• Flash Point: 173℃
• PSA: 24.92000
• Density: 1.555
• LogP: 3.11200
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-N-methylquinolin-4-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-N-methyl-4-quinolinamine

There total 6 articles about 6-Bromo-N-methyl-4-quinolinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

6-bromo-4-chloroquinoline (65340-70-7) + methylamine (74-89-5) → 6-bromo-N-methyl-4-quinolinamine (916812-31-2)

Guidance literature:

In methanol; at 120 ℃; for 3h; Microwave irradiation;

Reference yield:

6-bromoquinolin-4-ol (145369-94-4) → 6-bromo-N-methyl-4-quinolinamine (916812-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / Heating / reflux

2: methanol / 3 h / 120 °C / Microwave irradiation

With trichlorophosphate; In methanol;

Reference yield:

6-bromo-4-hydroxyquinoline-3-carboxylic acid (98948-95-9) → 6-bromo-N-methyl-4-quinolinamine (916812-31-2)

Guidance literature:

Multi-step reaction with 3 steps

1: diphenylether / 2 h / Heating / reflux

2: trichlorophosphate / Heating / reflux

3: methanol / 3 h / 120 °C / Microwave irradiation

With trichlorophosphate; In methanol; diphenylether;

upstream raw materials:

6-bromo-4-chloroquinoline

methylamine

6-bromoquinolin-4-ol

6-bromo-4-hydroxyquinoline-3-carboxylic acid

Refernces

• 1、 -. "NOVEL CHEMICAL COMPOUNDS". Page/Page column 46. . Retrieved 2010/11/25.