Technology Process of Methyl azepane-2-carboxylate
There total 9 articles about Methyl azepane-2-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methanol; (2R/S)-azepinecarboxylic acid;
With
thionyl chloride;
at 0 - 20 ℃;
With
sodium carbonate;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydroxylamine hydrochloride; pyridine / 0 - 20 °C
2.1: phosphorus pentoxide / water / 1 h / 130 - 140 °C
3.1: phosphorus pentachloride / dichloromethane; toluene / 2 h / Reflux
3.2: 16 h / pH 8 / Cooling with ice
4.1: hydrogen; sodium acetate / palladium 10% on activated carbon / acetic acid / 18 h / 20 °C
5.1: sodium hydroxide / 1,4-dioxane / 18 h / Reflux
5.2: 4 h / 20 °C
6.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
7.1: thionyl chloride / 0 - 20 °C
With
pyridine; thionyl chloride; phosphorus pentoxide; phosphorus pentachloride; hydroxylamine hydrochloride; hydrogen; sodium acetate; trifluoroacetic acid; sodium hydroxide;
palladium 10% on activated carbon;
In
1,4-dioxane; dichloromethane; water; acetic acid; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: phosphorus pentachloride / dichloromethane; toluene / 2 h / Reflux
1.2: 16 h / pH 8 / Cooling with ice
2.1: hydrogen; sodium acetate / palladium 10% on activated carbon / acetic acid / 18 h / 20 °C
3.1: sodium hydroxide / 1,4-dioxane / 18 h / Reflux
3.2: 4 h / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
5.1: thionyl chloride / 0 - 20 °C
With
thionyl chloride; phosphorus pentachloride; hydrogen; sodium acetate; trifluoroacetic acid; sodium hydroxide;
palladium 10% on activated carbon;
In
1,4-dioxane; dichloromethane; acetic acid; toluene;
