2-(4-(Methoxycarbonyl)pyridine-3-yl)Malonic Acid DiMethyl Ester

Base Information

• Chemical Name: 2-(4-(Methoxycarbonyl)pyridine-3-yl)Malonic Acid DiMethyl Ester
• CAS No.: 960114-13-0
• Molecular Formula: C₁₂H₁₃NO₆
• Molecular Weight: 267.238
• Hs Code.: 2933399090
• Mol file: 960114-13-0.mol

Synonyms:2-(4-(Methoxycarbonyl)pyridine-3-yl)malonic Acid Dimethyl Ester

Chemical Property of 2-(4-(Methoxycarbonyl)pyridine-3-yl)Malonic Acid DiMethyl Ester

Chemical Property:

• Vapor Pressure: 6.18E-06mmHg at 25°C
• Boiling Point: 378.7°C at 760 mmHg
• Flash Point: 182.8°C
• PSA: 91.79000
• Density: 1.268g/cm³
• LogP: 0.29780

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-(Methoxycarbonyl)pyridine-3-yl)Malonic Acid DiMethyl Ester

There total 1 articles about 2-(4-(Methoxycarbonyl)pyridine-3-yl)Malonic Acid DiMethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

methyl 3-nitropyridine-4-carboxylate (103698-10-8) + malonic acid dimethyl ester (108-59-8) → 2-(4-methoxycarbonyl-3-pyridyl)-propanedioic acid dimethyl ester (960114-13-0) + 2-(4-methoxycarbonyl-3-nitro-6-pyridyl)-propanedioic acid dimethyl ester

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 150 ℃;

DOI:10.1016/j.tet.2007.09.026

Reference yield: 31.0%

2-(4-methoxycarbonyl-3-pyridyl)-propanedioic acid dimethyl ester (960114-13-0) + benzoyl chloride (98-88-4) → 3-phenyl-1H-pyrano(4,3-c)pyridin-1-one (118160-04-6)

Guidance literature:

at 200 ℃; for 2h;

DOI:10.1016/j.tet.2007.09.026

Reference yield: 24.0%

2-(4-methoxycarbonyl-3-pyridyl)-propanedioic acid dimethyl ester (960114-13-0) + phenylacetyl chloride (103-80-0) → 3-benzylpyrano[4,3-c]pyridin-1-one

Guidance literature:

at 200 ℃; for 2h;

DOI:10.1016/j.tet.2007.09.026

upstream raw materials:

methyl 3-nitropyridine-4-carboxylate

malonic acid dimethyl ester

Downstream raw materials:

3-phenyl-1H-pyrano(4,3-c)pyridin-1-one