3-Hydroxy-3-methyl-azetidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 3-Hydroxy-3-methyl-azetidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1104083-23-9
• Molecular Formula: C9H17NO3
• Molecular Weight: 187.239
• Hs Code.: 2933990090
• Mol file: 1104083-23-9.mol

Synonyms:tert-butyl 3-hydroxy-3-methylazetidine-1-carboxylate;3-Hydroxy-3-methyl-azetidine-1-carboxylic acid tert-butyl ester;

Chemical Property of 3-Hydroxy-3-methyl-azetidine-1-carboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 257℃
• PKA: 14.23±0.20(Predicted)
• Flash Point: 110℃
• PSA: 49.77000
• Density: 1.137
• LogP: 0.92600
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-Hydroxy-3-methylazetidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Hydroxy-3-methyl-azetidine-1-carboxylic acid tert-butyl ester

There total 5 articles about 3-Hydroxy-3-methyl-azetidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-hydroxyl-3-methylazetidine hydrochloride (124668-46-8) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 3-hydroxy-3-methylazetidine-1-carboxylate (1104083-23-9)

Guidance literature:

3-hydroxyl-3-methylazetidine hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h;

di-tert-butyl dicarbonate; In dichloromethane; at 20 ℃; for 6h;

Reference yield: 99.0%

tert-butyl 3-oxoazetidine-1-carboxylate (398489-26-4) + methylmagnesium chloride (676-58-4) → tert-butyl 3-hydroxy-3-methylazetidine-1-carboxylate (1104083-23-9)

Guidance literature:

tert-butyl 3-oxoazetidine-1-carboxylate; methylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield: 87.0%

tert-butyl 3-oxoazetidine-1-carboxylate (398489-26-4) + methylmagnesium bromide (75-16-1) → tert-butyl 3-hydroxy-3-methylazetidine-1-carboxylate (1104083-23-9)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 3h;

upstream raw materials:

tert-butyl 3-oxoazetidine-1-carboxylate

methylmagnesium chloride

methylmagnesium bromide

tert-butyl 3-hydroxyazetidine-1-carboxylate

Downstream raw materials:

3-hydroxy-3-methyl azetidine

1-(Tert-butoxycarbonyl)-3-methoxy-3-methylazetidine

3-hydroxyl-3-methylazetidine hydrochloride

tert-butyl 3-fluoro-3-methylazetidine-1-carboxylate