Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Base Information

• Chemical Name: Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate
• CAS No.: 1196156-42-9
• Molecular Formula: C8H7N3O2
• Molecular Weight: 177.162
• Hs Code.: 2933990090
• Mol file: 1196156-42-9.mol

Synonyms:Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate;1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, Methyl ester

Chemical Property of Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Chemical Property:

• PSA: 67.87000
• LogP: 0.74450
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate

There total 6 articles about Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

methanol (67-56-1) + 1H-pyrazolo[3,4-b] pyridine-5-carboxylic acid (952182-02-4) → 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester (1196156-42-9)

Guidance literature:

With sulfuric acid; for 18h; Inert atmosphere; Reflux;

DOI:10.1002/anie.201507266

Reference yield: 59.0%

→ 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester (1196156-42-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h;

Reference yield: 46.0%

methanol (67-56-1) + 5-bromo-7-azaindazole (875781-17-2,916257-29-9) + carbon monoxide (201230-82-2) → 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester (1196156-42-9)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 12h;

upstream raw materials:

methanol

5-bromo-7-azaindazole

carbon monoxide

1H-pyrazolo[3,4-b] pyridine-5-carboxylic acid

Downstream raw materials:

N-(2-methyl-5-((4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)phenyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

1H-pyrazolo[3,4-b] pyridine-5-carboxylic acid

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