dimethyl spiro[3.3]heptane-2,6-dicarboxylate

Base Information

• Chemical Name: dimethyl spiro[3.3]heptane-2,6-dicarboxylate
• CAS No.: 27259-79-6
• Molecular Formula: C₁₁H₁₆O₄
• Molecular Weight: 212.246
• Mol file: 27259-79-6.mol

Synonyms:dimethyl spiro[3.3]heptane-2,6-dicarboxylate;(+)-Spiro[3.3]heptane-2,6-dicarboxylic acid dimethyl ester;Spiro[3.3]heptane-2,6-dicarboxylic acid, dimethyl ester, (+)- (8CI)

Chemical Property of dimethyl spiro[3.3]heptane-2,6-dicarboxylate

Chemical Property:

• Boiling Point: 264℃
• Flash Point: 124℃
• Density: 1.17

Purity/Quality:

98% ^*data from raw suppliers

Dimethylspiro[3.3]heptane-2,6-dicarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl spiro[3.3]heptane-2,6-dicarboxylate

There total 6 articles about dimethyl spiro[3.3]heptane-2,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + spiro[3.3]heptane-2,6-dicarbonyl dichloride (52097-87-7,60334-24-9) → dimethyl spiro[3.3]heptane-2,6-dicarboxylate (27259-79-6,37942-79-3)

Guidance literature:

In dichloromethane; at 20 ℃; Cooling with ice; Inert atmosphere;

DOI:10.1021/jo901892d

Reference yield: 37.0%

spiro[3.3]heptane-2,6-dicarboxylic acid (3057-91-8,27259-78-5,52193-74-5) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → dimethyl spiro[3.3]heptane-2,6-dicarboxylate (27259-79-6,37942-79-3) + Methyl-hydrogen-spiro<3.3>heptan-2,6-dicarboxylat (10481-25-1)

Guidance literature:

In N,N-dimethyl-formamide; for 16h; Ambient temperature;

DOI:10.1021/jo00125a011

Reference yield:

methanol (67-56-1) → dimethyl spiro[3.3]heptane-2,6-dicarboxylate (27259-79-6,37942-79-3)

Guidance literature:

With sulfuric acid;

upstream raw materials:

methanol

spiro[3.3]heptane-2,6-dicarbonyl dichloride

spiro[3.3]heptane-2,6-dicarboxylic acid

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

2,6-di(diphenylhydroxymethyl)spiro[3.3]heptane

Methyl-hydrogen-spiro<3.3>heptan-2,6-dicarboxylat

spiro[3.3]heptane-2,6-dicarboxylic acid

Refernces

• 1、 Weatherhead, Robin A.,Carducci, Michael D.,Mash, Eugene A.. "Synthesis of conformationally constrained diaminodicarboxylic acid derivatives". experimental part. p. 8773 - 8778. Retrieved 2010/03/02.
• 2、 Jones,Drach,Corbett,Kessel,Zemlicka. "(±)-N9-(2-(hydroxymethyl)spiro[3.3]hept-6-yl)adenine. The first biologically active saturated analogue of adenallene with axial dissymmetry". . p. 6277 - 6280. Retrieved 2007/10/03.