2-AMINO-5,6,7,8-TETRAHYDRO-QUINAZOLIN-4-OL

Base Information

• Chemical Name: 2-AMINO-5,6,7,8-TETRAHYDRO-QUINAZOLIN-4-OL
• CAS No.: 33081-07-1
• Molecular Formula: C8H11N3O
• Molecular Weight: 165.19
• Hs Code.: 2933990090
• Mol file: 33081-07-1.mol

Synonyms:BUTTPARK 15\02-44;2-AMINO-5,6,7,8-TETRAHYDRO-QUINAZOLIN-4-OL;2-AMINO-4-HYDROXY-5,6,7,8-TETRAHYDROQUINAZOLINE;2-AMINO-5,6,7,8-TETRAHYDRO-4-QUINAZOLINOL;2-amino-5,6,7,8-tetrahydro-4-quinazolinol(SALTDATA: FREE);

Chemical Property of 2-AMINO-5,6,7,8-TETRAHYDRO-QUINAZOLIN-4-OL

Chemical Property:

• Vapor Pressure: 0.000105mmHg at 25°C
• Melting Point: 284-288 °C
• Boiling Point: 337.4°C at 760 mmHg
• PKA: 3.00±0.20(Predicted)
• Flash Point: 157.9°C
• PSA: 72.03000
• Density: 1.53g/cm³
• LogP: 1.22440

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-5,6,7,8-tetrahydro-1H-quinazolin-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5,6,7,8-TETRAHYDRO-QUINAZOLIN-4-OL

There total 7 articles about 2-AMINO-5,6,7,8-TETRAHYDRO-QUINAZOLIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

guanidine hydrogen carbonate (124-46-9,20734-13-8,100224-74-6,593-85-1,90332-86-8,3425-08-9) + ethyl 2-oxocyclohexane carboxylate (1655-07-8) → 2-amino-4-hydroxy-5,6-tetramethylenepyrimidine (33081-07-1)

Guidance literature:

In ethanol;

Reference yield: 60.0%

2-bromocyclohex-1-enecarboxylic acid (68965-62-8) + guanidine hydrochloride (50-01-1) → 2-amino-5,6,7,8-tetrahydroquinazolin-4-one (33081-07-1)

Guidance literature:

guanidine hydrochloride; With copper(l) iodide; caesium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 0.25h; Inert atmosphere;

2-bromocyclohex-1-enecarboxylic acid; In N,N-dimethyl-formamide; at 40 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0030-1258803

Reference yield:

guanidine hydrochloride (50-01-1) + 2-(methoxycarbonyl)cyclohexanone (41302-34-5) → 2-amino-4-hydroxy-5,6-tetramethylenepyrimidine (33081-07-1)

Guidance literature:

With potassium tert-butylate; In methanol; at 23 - 60 ℃;

DOI:10.1021/jm401727m

upstream raw materials:

guanidine nitrate

ethyl 2-oxocyclohexane carboxylate

guanidine hydrochloride

2-bromocyclohex-1-enecarboxylic acid

Downstream raw materials:

4-chloro-5,6,7,8-tetrahydroquinazoline-2-ylamine

Refernces

• 1、 Guo, Qi,Yang, Haijun,Liu, Hongxia,Jiang, Yuyang,Fu, Hua. "Easy and efficient copper-catalyzed synthesis of bicyclic pyrimidinones under mild conditions". experimental part. p. 2611 - 2616. Retrieved 2010/11/24.
• 2、 Gangjee, Aleem,Vasudevan, Anil,Kisliuk, Roy L.. "Nonclassical 5-substituted tetrahydroquinazolines as potential inhibitors of thymidylate synthase". . p. 1669 - 1676. Retrieved 2007/10/03.