4-Ethoxy-2-methylquinazoline

Base Information

• Chemical Name: 4-Ethoxy-2-methylquinazoline
• CAS No.: 91350-36-6
• Molecular Formula: C11H12N2O
• Molecular Weight: 188.229
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40356538
• Wikidata: Q82135930
• Mol file: 91350-36-6.mol

Synonyms:4-ethoxy-2-methylquinazoline;91350-36-6;DTXSID40356538;AKOS006241581;AE-562/12222383

Chemical Property of 4-Ethoxy-2-methylquinazoline

Chemical Property:

• Boiling Point: 241.0±23.0 °C(Predicted)
• PKA: 4.72±0.50(Predicted)
• PSA: 35.01000
• Density: 1.128±0.06 g/cm3(Predicted)
• LogP: 2.33690
• Storage Temp.: 2-8°C
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 188.094963011
• Heavy Atom Count: 14
• Complexity: 186

Purity/Quality:

4-Ethoxy-2-methylquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=NC(=NC2=CC=CC=C21)C

Technology Process of 4-Ethoxy-2-methylquinazoline

There total 3 articles about 4-Ethoxy-2-methylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-methyl-5H-1,4,2-dioxazol-5-one + benzimidic acid ethyl ester (825-60-5) → 4-ethoxy-2-methylquinazoline (91350-36-6)

Guidance literature:

With silver hexafluoroantimonate; carbonyl(pentamethylcyclopentadienyl)cobalt diiodide; sodium acetate; In 1,2-dichloro-ethane; at 60 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.6b00716

Reference yield:

sodium ethanolate (141-52-6) + 2-acetamidobenzonitrile (25116-00-1) → 4-ethoxy-2-methylquinazoline (91350-36-6)

Guidance literature:

Reference yield:

→ 4-ethoxy-2-methylquinazoline (91350-36-6)

Guidance literature:

4-Mercapto-2-methyl-chinazolin, 1. aethanol. NaOC2H5 (5 Mol), Erwaermen, 2. Aethylbromid;

upstream raw materials:

sodium ethanolate

2-acetamidobenzonitrile

benzimidic acid ethyl ester

Downstream raw materials:

2-methyl-4-quinazolone

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