ETHYL 3-(N-METHYLAMINO) PROPIONATE

Base Information

• Chemical Name: ETHYL 3-(N-METHYLAMINO) PROPIONATE
• CAS No.: 2213-08-3
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.175
• Hs Code.: 2922499990
• Mol file: 2213-08-3.mol

Synonyms:.beta.-Alanine, N-methyl-, ethyl ester; 3-(Methylamino)propionic acid ethyl ester; beta-alanine, N-methyl-, ethyl ester; Ethyl N-methyl-beta-alaninate

Chemical Property of ETHYL 3-(N-METHYLAMINO) PROPIONATE

Chemical Property:

• Vapor Pressure: 1.27mmHg at 25°C
• Refractive Index: 1.4443 (estimate)
• Boiling Point: 173.5°C at 760 mmHg
• PKA: 9.55±0.10(Predicted)
• Flash Point: 58.7°C
• PSA: 38.33000
• Density: 0.937g/cm³
• LogP: 0.54990
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98.5% ^*data from raw suppliers

Ethyl N-Methyl-beta-alaninate ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

Useful:

Technology Process of ETHYL 3-(N-METHYLAMINO) PROPIONATE

There total 14 articles about ETHYL 3-(N-METHYLAMINO) PROPIONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methylamine (74-89-5) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 3-methylaminopropionate (2213-08-3)

Guidance literature:

With caesium fluoride; In water monomer; for 0.666667h; Sonication; Irradiation;

DOI:10.1007/s00706-011-0550-2

Reference yield: 67.0%

→ 2-[2-Ethoxy-5-(N-2-ethoxycarbonylethyl-N-methyl-sulphamoyl)phenyl]-8-n-prolylpyrido[3,2-d]pyrimidin-(3H)-one + ethyl 3-methylaminopropionate (2213-08-3)

Guidance literature:

Reference yield: 67.0%

→ 2-[2-Ethoxy-5-(N-2-ethoxycarbonylethyl-N-methyl-sulphamoyl) phenyl]-8-n-propylpyrido[3,2-d]pyrimidin-4(3H)-one (155879-57-5) + ethyl 3-methylaminopropionate (2213-08-3)

Guidance literature:

upstream raw materials:

N-(2-cyanoethyl)-N-methylamine

ethanol

methylamine

ethyl acrylate

Downstream raw materials:

3,3'-methylimino-di-propionic acid diethyl ester

3-((ethoxycarbonylmethyl)methylamino)propionic acid ethyl ester

2-{2-[(2-ethoxycarbonyl-ethyl)-methyl-amino]-1-methoxycarbonyl-ethyl}-benzoic acid methyl ester

(R)-3-{[(2-Ethoxycarbonyl-ethyl)-methyl-amino]-methyl}-4-(4-methoxy-phenyl)-butyric acid ethyl ester

Refernces

• 1、 Gaunt, Matthew J.,Miró, Javier,Reeve, Luke A.,Rodrigalvarez, Jesus. "Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Cyclopropanes and Cyclobutanes Guided by Tertiary Alkylamines". supporting information. p. 3939 - 3948. Retrieved 2022/03/08.
• 2、 Labade, Vilas B.,Pawar, Shivaji S.,Shingare, Murlidhar S.. "Cesium fluoride catalyzed Aza-Michael addition reaction in aqueous media". experimental part. p. 1055 - 1059. Retrieved 2012/07/27.