tert-Butyl 2,8-diazaspiro[5.5]undecane-2-carboxylate

Base Information

• Chemical Name: tert-Butyl 2,8-diazaspiro[5.5]undecane-2-carboxylate
• CAS No.: 954240-14-3
• Molecular Formula: C14H26N2O2
• Molecular Weight: 254.37
• Hs Code.: 2933990090
• Mol file: 954240-14-3.mol

Synonyms:2,8-Diazaspiro[5.5]undecane-2-carboxylicacid1,1-dimethylethylester;

Chemical Property of tert-Butyl 2,8-diazaspiro[5.5]undecane-2-carboxylate

Chemical Property:

• Vapor Pressure: 3.42E-05mmHg at 25°C
• Refractive Index: 1.512
• Boiling Point: 354.137 °C at 760 mmHg
• Flash Point: 167.977 °C
• PSA: 41.57000
• Density: 1.058 g/cm³
• LogP: 2.65380
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

2,8-Diazaspiro[5.5]undecane-2-carboxylicacidtert-butylester 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 2,8-diazaspiro[5.5]undecane-2-carboxylate

There total 2 articles about tert-Butyl 2,8-diazaspiro[5.5]undecane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2,8-di-(tert-butyloxycarbonyl)-2,8-diazaspiro[5.5]undecane (1433194-67-2) → 2,8-diazaspiro[5.5]undecane-2-carboxylic acid tert-butyl ester (954240-14-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tet.2013.03.064

Reference yield:

2,8-diazaspiro[5.5]undecane (180-50-7) → 2,8-diazaspiro[5.5]undecane-2-carboxylic acid tert-butyl ester (954240-14-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; water;

DOI:10.1016/j.tet.2013.03.064

Reference yield:

2,8-diazaspiro[5.5]undecane-2-carboxylic acid tert-butyl ester (954240-14-3) + 2-{[3-(3-chlorophenyl)-8-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]thio}-4-(1,3-dioxo-1,3-dihydro-2-1H-isoindol-2-yl)butanoic acid (1181220-78-9) → tert-butyl 8-[2-{[3(3-chlorophenyl)-8-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]thio}-4-(1,3-dioxo4,3-dihydro-2H-isoindol-2-yl)butanoyl]-2,8-diazaspiro[5.5]undecane-2-carboxylate

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

2,8-diazaspiro[5.5]undecane

2,8-di-(tert-butyloxycarbonyl)-2,8-diazaspiro[5.5]undecane

Downstream raw materials:

tert-butyl 8-(2-{[3-(3-chlorophenyl)-8-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]thio}hexanoyl)-2,8-diazaspiro[5.5]undecane-2-carboxylate

8-(3-(4-chlorophenoxy)benzyl)-N-(pyridin-3-yl)-2,8-diazaspiro[5.5]undecane-2-carboxamide