Methyl 2-(1,3-dioxoisoindol-2-yl)-2-(2-nitrophenyl)acetate

Base Information

Chemical Name:Methyl 2-(1,3-dioxoisoindol-2-yl)-2-(2-nitrophenyl)acetate
CAS No.:50381-55-0
Molecular Formula:C₁₇H₁₂N₂O₆
Molecular Weight:340.292
Hs Code.:
DSSTox Substance ID:DTXSID60442265
Mol file:50381-55-0.mol

Synonyms:50381-55-0;Methyl 2-(1,3-dioxoisoindol-2-yl)-2-(2-nitrophenyl)acetate;AGN-PC-0N76S9;F2147-1156;DTXSID60442265;AKOS026715450;FT-0764910;methyl (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)(2-nitrophenyl)acetate

Suppliers and Price of Methyl 2-(1,3-dioxoisoindol-2-yl)-2-(2-nitrophenyl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2H-ISOINDOLE-2-ACETIC ACID, .ALPHA.-(3-AMINO-3-OXOPROPYL)-1,3-DIHYDRO-1,3-DIOXO-, (.ALPHA.S)- 95.00%
5MG
$ 503.91

Total 2 raw suppliers

Chemical Property of Methyl 2-(1,3-dioxoisoindol-2-yl)-2-(2-nitrophenyl)acetate

Chemical Property:

PSA：109.50000
LogP:2.56620
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:340.06953611
Heavy Atom Count:25
Complexity:562

Purity/Quality:

98%min ^*data from raw suppliers

2H-ISOINDOLE-2-ACETIC ACID, .ALPHA.-(3-AMINO-3-OXOPROPYL)-1,3-DIHYDRO-1,3-DIOXO-, (.ALPHA.S)- 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C(C1=CC=CC=C1[N+](=O)[O-])N2C(=O)C3=CC=CC=C3C2=O

Technology Process of Methyl 2-(1,3-dioxoisoindol-2-yl)-2-(2-nitrophenyl)acetate

There total 4 articles about Methyl 2-(1,3-dioxoisoindol-2-yl)-2-(2-nitrophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 42794-41-2
methyl α-bromo-2-nitrophenylacetate

: 1074-82-4
potassium phtalimide

: 50381-55-0
methyl α-phthalimido-2-nitrophenylacetate

Guidance literature:: In N,N-dimethyl-formamide; for 2h;
DOI:10.1021/jo9917846

Reference yield:

: 30095-98-8
methyl (2-nitrophenyl)acetate

: 50381-55-0
methyl α-phthalimido-2-nitrophenylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 22 percent / NBS; benzoyl peroxide / CCl₄ / 72 h / Heating

2: 90 percent / dimethylformamide / 2 h

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide; 1: Bromination / 2: Substitution;
DOI:10.1021/jo9917846

Reference yield:

: 3740-52-1
2-(2-nitrophenyl)acetic acid

: 50381-55-0
methyl α-phthalimido-2-nitrophenylacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / NaHCO₃ / dimethylformamide / 8 h

2: 22 percent / NBS; benzoyl peroxide / CCl₄ / 72 h / Heating

3: 90 percent / dimethylformamide / 2 h

With N-Bromosuccinimide; sodium hydrogencarbonate; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide; 1: Methylation / 2: Bromination / 3: Substitution;
DOI:10.1021/jo9917846