2-Amino-2-(2-nitrophenyl)acetic acid hydrochloride

Base Information

• Chemical Name: 2-Amino-2-(2-nitrophenyl)acetic acid hydrochloride
• CAS No.: 50357-25-0
• Molecular Formula: C₈H₈N₂O₄*ClH
• Molecular Weight: 232.623
• Hs Code.: 2922499990
• DSSTox Substance ID: DTXSID60696327
• Mol file: 50357-25-0.mol

Synonyms:50357-25-0;2-amino-2-(2-nitrophenyl)acetic acid hydrochloride;AMINO-(2-NITRO-PHENYL)-ACETIC ACID HYDROCHLORIDE;amino(2-nitrophenyl)acetic acid hydrochloride;2-amino-2-(2-nitrophenyl)acetic acid;hydrochloride;2-Amino-2-(2-nitrophenyl)acetic acid HCl;C8H9ClN2O4;DTXSID60696327;MFCD11506322;AKOS024261889;SB37379;EN300-235048;2-amino-2-(2-nitrophenyl)aceticacidhydrochloride;F2147-1029;Amino(2-nitrophenyl)acetic acid--hydrogen chloride (1/1);2-Amino-2-(2-nitrophenyl)acetic acid hydrochloride (H-DL-Phg(2-NO2)-OH.HCl)

Chemical Property of 2-Amino-2-(2-nitrophenyl)acetic acid hydrochloride

Chemical Property:

• PSA: 109.14000
• LogP: 2.70470
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 232.0250845
• Heavy Atom Count: 15
• Complexity: 238

Purity/Quality:

97% ^*data from raw suppliers

Amino-(2-nitro-phenyl)-aceticacidhydrochloride 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(C(=O)O)N)[N+](=O)[O-].Cl

Technology Process of 2-Amino-2-(2-nitrophenyl)acetic acid hydrochloride

There total 4 articles about 2-Amino-2-(2-nitrophenyl)acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl α-phthalimido-2-nitrophenylacetate (50381-55-0) → (+/-)-2-nitrophenylglycine hydrochloride (50357-25-0)

Guidance literature:

With hydrogenchloride; acetic acid; for 4h; Heating;

DOI:10.1021/jo9917846

Reference yield:

2-(2-nitrophenyl)acetic acid (3740-52-1) → (+/-)-2-nitrophenylglycine hydrochloride (50357-25-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / NaHCO₃ / dimethylformamide / 8 h

2: 22 percent / NBS; benzoyl peroxide / CCl₄ / 72 h / Heating

3: 90 percent / dimethylformamide / 2 h

4: 80 percent / aq. HCl; AcOH / 4 h / Heating

With hydrogenchloride; N-Bromosuccinimide; sodium hydrogencarbonate; acetic acid; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide; 1: Methylation / 2: Bromination / 3: Substitution / 4: Hydrolysis;

DOI:10.1021/jo9917846

Reference yield:

methyl (2-nitrophenyl)acetate (30095-98-8) → (+/-)-2-nitrophenylglycine hydrochloride (50357-25-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 22 percent / NBS; benzoyl peroxide / CCl₄ / 72 h / Heating

2: 90 percent / dimethylformamide / 2 h

3: 80 percent / aq. HCl; AcOH / 4 h / Heating

With hydrogenchloride; N-Bromosuccinimide; acetic acid; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide; 1: Bromination / 2: Substitution / 3: Hydrolysis;

DOI:10.1021/jo9917846

upstream raw materials:

methyl α-phthalimido-2-nitrophenylacetate

2-(2-nitrophenyl)acetic acid

methyl (2-nitrophenyl)acetate

methyl α-bromo-2-nitrophenylacetate

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