(2-isopropyloxazol-4-yl)MethanaMine hydrochloride

Base Information

• Chemical Name: (2-isopropyloxazol-4-yl)MethanaMine hydrochloride
• CAS No.: 15924-16-0
• Molecular Formula: C9H9Cl2NO3
• Molecular Weight: 177
• Hs Code.: 2922500090
• Mol file: 15924-16-0.mol

Synonyms:(2-isopropyloxazol-4-yl)MethanaMine hydrochloride

Chemical Property of (2-isopropyloxazol-4-yl)MethanaMine hydrochloride

Chemical Property:

• Boiling Point: 392.5±42.0 °C(Predicted)
• PKA: 2.17±0.30(Predicted)
• Density: 1.565±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-isopropyloxazol-4-yl)MethanaMine hydrochloride

There total 13 articles about (2-isopropyloxazol-4-yl)MethanaMine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,5-dichloro-L-tyrosine methyl ester (127526-66-3) → (S)-2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoic acid (15106-62-4,15924-16-0)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; methanol; water; at 20 ℃; for 24h;

DOI:10.21577/0103-5053.20180136

Reference yield: 80.0%

tyrosine (556-02-5,18875-48-4,25619-78-7,30704-25-7) → (R)-2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoic acid (15924-16-0)

Guidance literature:

With sulfuryl dichloride; In acetic acid; for 5h; Ambient temperature;

DOI:10.1021/ja00154a002

Reference yield: 74.0%

(S)-4-(3,5-Dichloro-4-hydroxy-benzyl)-5-oxo-oxazolidine-3-carboxylic acid benzyl ester → (S)-2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoic acid (15106-62-4,15924-16-0)

Guidance literature:

With boron trichloride; In dichloromethane; at 25 ℃; for 0.333333h;

DOI:10.1016/j.tetlet.2004.06.011

upstream raw materials:

(S)-2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoic acid

5-(3,5-dichloro-4-hydroxy-benzyl)-imidazolidine-2,4-dione

?Tyr

L-tyrosine

Downstream raw materials:

2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoic acid

(S)-2-Benzyloxycarbonylamino-3-(3,5-dichloro-4-methoxy-phenyl)-propionic acid methyl ester

C₁₄H₁₇Cl₂NO₅