1-[4-(2,2-Dichlorocyclopropyl)phenyl]ethan-1-one

Base Information

• Chemical Name: 1-[4-(2,2-Dichlorocyclopropyl)phenyl]ethan-1-one
• CAS No.: 40641-93-8
• Molecular Formula: C11H10Cl2O
• Molecular Weight: 229.106
• Hs Code.: 2914700090
• European Community (EC) Number: 609-853-9,921-322-6
• DSSTox Substance ID: DTXSID90369537
• Mol file: 40641-93-8.mol

Synonyms:40641-93-8;1-(4-(2,2-Dichlorocyclopropyl)phenyl)ethanone;1-[4-(2,2-dichlorocyclopropyl)phenyl]ethan-1-one;1-[4-(2,2-dichlorocyclopropyl)phenyl]ethanone;1-(4-(2,2-Dichlorocyclopropyl)phenyl)ethan-1-one;Maybridge1_006764;SCHEMBL6429082;HMS560L10;DTXSID90369537;CCG-48711;AKOS015999683;FT-0755123;A873261;SR-01000638230-1;4-(2,2-dichlorocyclopropyl)-acetophenone

Chemical Property of 1-[4-(2,2-Dichlorocyclopropyl)phenyl]ethan-1-one

Chemical Property:

• Vapor Pressure: 4.68E-05mmHg at 25°C
• Melting Point: 35 °C
• Boiling Point: 349.5°C at 760 mmHg
• Flash Point: 147.6°C
• PSA: 17.07000
• Density: 1.31
• LogP: 3.55040
• Storage Temp.: 2-8°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 228.0108703
• Heavy Atom Count: 14
• Complexity: 242

Purity/Quality:

99% ^*data from raw suppliers

1-(4-(2,2-Dichlorocyclopropyl)phenyl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)C2CC2(Cl)Cl

Technology Process of 1-[4-(2,2-Dichlorocyclopropyl)phenyl]ethan-1-one

There total 1 articles about 1-[4-(2,2-Dichlorocyclopropyl)phenyl]ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1,1-dichloro-2-phenylcyclopropane (2415-80-7) + acetyl chloride (75-36-5) → 1-(4-acetylphenyl)-2,2-dichlorocyclopropane (40641-93-8)

Guidance literature:

With aluminium trichloride; In tetrachloromethane; at 10 - 15 ℃; for 6h;

Reference yield: 92.1%

1-(4-acetylphenyl)-2,2-dichlorocyclopropane (40641-93-8) → 4-(2,2-dichlorocyclopropyl)phenyl acetate (144900-34-5)

Guidance literature:

With dihydrogen peroxide; acetic anhydride; acetic acid; iron(II) chloride; at 40 ℃; for 4h; Reagent/catalyst;

Reference yield: 82.0%

1-(4-acetylphenyl)-2,2-dichlorocyclopropane (40641-93-8) + benzaldehyde (100-52-7) → 1,1-dichloro-2-(4-cinnamoylphenyl)cyclopropane

Guidance literature:

With hydroxide; In methanol;

upstream raw materials:

1,1-dichloro-2-phenylcyclopropane

acetyl chloride

Downstream raw materials:

[4-(2,2-Dichloro-cyclopropyl)-phenyl]-acetic acid methyl ester

α-(p-2,2-Dichlorcyclopropylphenyl)aethanol

1-(2,2-Dichloro-cyclopropyl)-4-isopropenyl-benzene

1-(4-acetylphenyl)-2,2-dimethoxycyclopropane

Refernces

• 1、 Tishchenko, I. G.,Kulinkovich, O. G.. "REACTION OF 1-(4-ACETYLPHENYL)- AND 1-(4-FORMYLPHENYL)-2,2-DICHLOROCYCLOPROPANES WITH SODIUM ALCOHOLATES". . p. 268 - 271. Retrieved 2007/10/02.