N-Methyl-1-(piperidin-2-yl)methanamine

Base Information

• Chemical Name: N-Methyl-1-(piperidin-2-yl)methanamine
• CAS No.: 27643-19-2
• Molecular Formula: C7H16N2
• Molecular Weight: 128.217
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50486936
• Mol file: 27643-19-2.mol

Synonyms:27643-19-2;N-Methyl-1-(piperidin-2-yl)methanamine;methyl-piperidin-2-ylmethyl-amine;methyl[(piperidin-2-yl)methyl]amine;N-methyl-1-piperidin-2-ylmethanamine;SCHEMBL2919671;DTXSID50486936;CBA64319;AKOS010394498;N-METHYL-2-PIPERIDINEMETHANAMINE;AM100614;FT-0688696;EN300-399795;F1911-1644

Chemical Property of N-Methyl-1-(piperidin-2-yl)methanamine

Chemical Property:

• Boiling Point: 176℃
• Flash Point: 55℃
• PSA: 24.06000
• Density: 0.861
• LogP: 1.06760
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 128.131348519
• Heavy Atom Count: 9
• Complexity: 73.3

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCC1CCCCN1
• Uses: Methyl[(piperidin-2-yl)methyl]amine is a useful reagent in the synthesis of 2-?azaindolizidines and some other related derivatives.

Technology Process of N-Methyl-1-(piperidin-2-yl)methanamine

There total 5 articles about N-Methyl-1-(piperidin-2-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

N-methyl-2-pyridinemethanamine (21035-59-6) → 2-Methylaminomethyl-piperidin (27643-19-2)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid; under 3102.9 Torr;

DOI:10.1002/mrc.1260250808

Reference yield:

pyridine-2-carbaldehyde (1121-60-4) → 2-Methylaminomethyl-piperidin (27643-19-2)

Guidance literature:

Multi-step reaction with 3 steps

1: benzene / Heating

2: sodium borohydride / methanol / 3 h

3: 51 percent / hydrogen / Adams platinum oxide / acetic acid / 3102.9 Torr

With sodium tetrahydroborate; hydrogen; platinum(IV) oxide; In methanol; acetic acid; benzene;

DOI:10.1002/mrc.1260250808

Reference yield:

N-(2-pyridylmethylene)methylamine (7032-20-4) → 2-Methylaminomethyl-piperidin (27643-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium borohydride / methanol / 3 h

2: 51 percent / hydrogen / Adams platinum oxide / acetic acid / 3102.9 Torr

With sodium tetrahydroborate; hydrogen; platinum(IV) oxide; In methanol; acetic acid;

DOI:10.1002/mrc.1260250808

upstream raw materials:

N-methyl-2-pyridinemethanamine

pyridine-2-carbaldehyde

N-(2-pyridylmethylene)methylamine