21035-59-6

Usage

Uses

Used in Pharmaceutical Industry:
METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE is used as a reagent for the preparation and structure-activity relationship of imidazolopyrimidones. These imidazolopyrimidones act as gonadotropin-releasing hormone (GnRH) receptor antagonists, which are important in the treatment of various conditions related to the hormonal regulation, such as endometriosis, uterine fibroids, and certain types of cancers.
The compound's role in the development of GnRH receptor antagonists is crucial, as it helps researchers understand the structure and function of these receptors, leading to the design of more effective and targeted therapies. By using METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE as a reagent, scientists can synthesize and test new imidazolopyrimidone derivatives, potentially discovering more potent and selective GnRH antagonists for clinical use.

InChI:InChI=1/C7H10N2/c1-8-6-7-4-2-3-5-9-7/h2-5,8H,6H2,1H3

Upstream product

• 42182-32-1 2-(N-Methyl-N-formyl-aminomethyl)-pyridin 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 74-89-5 methylamine 
• 4377-33-7 2-chloromethylpyridine 
• 56625-03-7 N-((pyridin-2-yl)methyl)formamide 
• 74-88-4 methyl iodide 
• 6144-78-1 N-methylpyridine-2-carboxamide 
• 134807-28-6 2-[N-(tert-butoxycarbonyl)aminomethyl]pyridine 
• 134807-29-7 2-<methyl>pyridine 
• 7032-20-4 N-(2-pyridylmethylene)methylamine 
• 593-51-1 methylamine hydrochloride 
• 6959-47-3 2-chloromethylpyridine hydrochloride 

Downstream Products

• 1151762-02-5 4,4-difluoro-8-{3,5-bis[2-(2-(2-hydroxyethoxy)ethoxy)ethoxy]phenyl}-1,3,5,7-tetramethyl-2,6-bis{2-[methyl(pyridin-2-ylmethyl)amino]methylpyridin-5-yl}-4-bora-3a,4a-diaza-s-indacene 
• 760981-62-2 ethyl {4-{2-{4-[(methylpyridin-2-ylmethylamino)methyl]-1H-benzimidazol-2-yl}phenylsulfamoyl}phenoxy}acetate 

Relevant academic research and scientific papers

Design and synthesis of a highly sensitive off-on fluorescent chemosensor for zinc ions utilizing internal charge transfer

Fluorescence imaging is a powerful tool for the visualization of biological molecules in living cells, tissue slices, and whole bodies, and is important for elucidating biological phenomena. Furthermore, zinc (Zn2+) is the second most abundant heavy metal ion in the human body after iron, and detection of chelatable Zn2+ in biological studies has attracted much attention. Herein, we present a novel, highly sensitive off-on fluorescent chemosensor for Zn2+ by using the internal charge transfer (ICT) mechanism. The rationale of our approach to highly sensitive sensor molecules is as follows. If fluorescence can be completely quenched in the absence of Zn2+, chemosensors would offer a better signal-to-noise ratio. However, it is difficult to quench the fluorescence completely before Zn 2+ binding, and most sensor molecules still show very weak fluorescence in the absence of Zn2+. But even though the sensor shows a weak fluorescence in the absence of Zn2+, this fluorescence can be further suppressed by selecting an excitation wavelength that is barely absorbed by the Zn2+-free sensor molecule. Focusing on careful control of ICT within the 4-amino-1,8-naphthalimide dye platform, we designed and synthesized a new chemosensor (1) that shows a pronounced fluorescence enhancement with a blueshift in the absorption spectrum upon addition of Zn 2+. The usefulness of 1 for monitoring Zn2+ changes was confirmed in living HeLa cells. There have been several reports on 4-amino-1,8-naphthalimide-based fluorescent sensor molecules. However, 1 is the first Zn2+-sensitive off-on fluorescent sensor molecule that employs the ICT mechanism; most off-on sensor molecules for Zn2+ employ the photoinduced electron transfer (PeT) mechanism.

Base-Promoted Tandem Synthesis of 2-Azaaryl Tetrahydroquinolines

A novel method to synthesize 2-azaaryl tetrahydroquinolines by the base-promoted tandem reaction of azaaryl methyl amines and styrene derivatives is reported (over 30 examples, yields up to 95%). Mechanistic probe experiments demonstrate that the deprotonation of the benzylic C-H bond and the addition to the styrene vinyl group proceeds via the SNAr mechanism.

4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice

Emergence of drug resistant Plasmodium falciparum including artemisinin-tolerant parasites highlights the need for new antimalarials. We have previously shown that dibemequines, 4-amino-7-chloroquinolines with dibenzylmethylamine (dibemethin) side chains, are efficacious. In this study, analogues in which the terminal phenyl group of the dibemethin was replaced with a 2-pyridyl group and in which the 4-amino-7-chloroquinoline was either maintained or replaced with a 4-aminoquinoline-7-carbonitrile were synthesized in an effort to improve druglikeness. These compounds exhibited significantly improved solubility and decreased lipophilicity and were potent against chloroquine-sensitive (NF54) and -resistant (Dd2 and 7G8) P. falciparum strains with 5/6 having IC50 100 nM against the NF54 strain. All inhibited both β-hematin (synthetic hemozoin) formation and hemozoin formation in the parasite. Parasitemia was reduced by over 90% in P. berghei infected mice in 3/6 derivatives following oral dosing at 4 × 30 mg/kg, with microsomal metabolic stability data suggesting that this could be attributed to highly active metabolites.

PRODRUGS OF PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETICS AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA

Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.

Amidation of unactivated ester derivatives mediated by trifluoroethanol

A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.

An iron(iii) tetradentate monoamido complex as a nonheme iron-based peroxidase mimetic

A mononuclear iron(iii) complex of a noncyclic tetradentate monoamido ligand, Fe(iii)mpaq, catalyses the oxidation of Orange II, guaiacol, ABTS and Amplex Red with H2O2 in aqueous solutions at neutral pH. Under identical conditions, other structurally related nonheme iron complexes showed only negligible activities.

An unusually stable octanuclear σ-mesityl-bridged μ4-oxo-copper(i) complex encapsulated by a pyrazolate-based compartmental ligand scaffold

A new compartmental pyrazole-derived chelating ligand, four equivalents of mesitylcopper and stoichiometric amounts of dioxygen lead to the formation of a remarkably stable organometallic framework that can be described as a heteroleptic O-centered cuprate anion [(MesCuI) 4(μ4-O)]2- linked via σ-mesityl- bridges to two surrounding binuclear CuI-pyrazolate clamps. The Royal Society of Chemistry.

Photoresponsive Heterocyclic Azo Compound, Method for Producing the Same, and Optical Information Recording Medium

There are provided a novel optical information recording material or medium excellent in various holographic optical information recording properties such as sensitivity, response speed, long-term storage stability, and repeatability, and a substance therefor. A photoresponsive heterocyclic azo compound contains an oligomer or polymer having a photoresponsive moiety in at least one of the main chain and side chain, and the photoresponsive moiety is a building block represented by the following formula (1): wherein HC1 and HC2 each represent a ring structure, at least one of them being a heterocyclic structure containing 1 or more heteroatom in the ring, R1 and R2 each represent a hydrogen atom or a substituent connected to the ring structure and may be the same or different ones, s and t each represent the number thereof, and X1 and X2 each represent a terminal group or a linking group, at least one of them being a linking group connected to the main chain of the oligomer or polymer and the terminal group being a hydrogen atom or a substituent.

Novel multicyclic compounds and the use thereof

The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.

Practical and efficient synthesis of C2 symmetrical diamines with Zn / Me3SiCl

C2 symmetrical diamines are efficiently obtained by reductive coupling of imines with the couple Zn/Me3SiCl. This high yielding method is very practical and cheap for large scale preparation.