METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE

Base Information

• Chemical Name: METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE
• CAS No.: 21035-59-6
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• European Community (EC) Number: 244-160-1
• NSC Number: 63910
• UNII: EBR8435235
• DSSTox Substance ID: DTXSID10175238
• Nikkaji Number: J225.381J
• Wikidata: Q83045520
• Mol file: 21035-59-6.mol

Synonyms:N-methyl-(pyridin-2-yl)methylamine;methyl(pyridin-2-ylmethyl)amine;2-[(Methylamino)methyl]pyridine;Methyl(2-pyridylmethyl)amine;N-Methylpyridine-2-methanamine;2-(N-methyl-aminomethyl)pyridine;N-Methyl-1-(pyridin-2-yl)methanamine;N-(picolyl-2)-methylamine;N-(pyridin-2-ylmethyl)-N-methylamine;Pyridine,2-(methylaminomethyl);2-[(methylamino)methyl]pyridine;N-methyl-N-(2-pyridinylmethyl)amine;2-Pyridinemethanamine,N-methyl;N-Methyl-N-(2-pyridylmethyl)amine;查看更多英文别名收起

Chemical Property of METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.966mmHg at 25°C
• Melting Point: 64 °C
• Refractive Index: 1.515
• Boiling Point: 178.9 °C at 760 mmHg
• PKA: pK1:2.92(＋2);pK2:8.82(＋1) (30°C)
• Flash Point: 62 °C
• PSA: 24.92000
• Density: 0.982 g/cm³
• LogP: 2.79590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 73.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-[(Methylamino)methyl]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CNCC1=CC=CC=N1
• Uses: 2-[(Methylamino)methyl]pyridine is used as a reagent in the preparation and structure activity relationship of imidazolopyrimidones as gonadotropin-releasing hormone (GnRH) receptor antagonists.

Technology Process of METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE

There total 17 articles about METHYLPYRIDIN-2-YLMETHYLAMINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

pyridine-2-carbaldehyde (1121-60-4) → N-methyl-2-pyridinemethanamine (21035-59-6)

Guidance literature:

With hydrogenchloride; sodium tetrahydroborate; methylamine; In ethanol; dichloromethane;

Reference yield: 74.0%

pyridine-2-carbaldehyde (1121-60-4) + methylamine (74-89-5) → N-methyl-2-pyridinemethanamine (21035-59-6)

Guidance literature:

pyridine-2-carbaldehyde; methylamine; In methanol; water; at 65 ℃; for 2h;

With sodium tetrahydroborate; In methanol; water; at 0 - 20 ℃; for 6h;

DOI:10.1021/acs.jmedchem.7b01537

Reference yield: 69.6%

2-chloromethylpyridine hydrochloride (6959-47-3) + methylamine (74-89-5) → N-methyl-2-pyridinemethanamine (21035-59-6)

Guidance literature:

In ethanol; water; for 96h; Ambient temperature;

upstream raw materials:

2-chloromethylpyridine hydrochloride

methylamine

pyridine-2-carbaldehyde

methylamine hydrochloride

Downstream raw materials:

2-Methylaminomethyl-piperidin

3-(4-cyano-phenyl)-1-methyl-1-pyridin-2-ylmethyl-thiourea

Refernces

• 1、 Chen, Shuguang,Yang, Langxuan,Shang, Yongjia,Mao, Jianyou,Walsh, Patrick J.. "Base-Promoted Tandem Synthesis of 2-Azaaryl Tetrahydroquinolines". supporting information. p. 1594 - 1599. Retrieved 2021/03/08.
• 2、 -. "PRODRUGS OF PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETICS AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA". Paragraph 00180. . Retrieved 2017/12/29.