2-cyclobutoxyacetic acid

Base Information

• Chemical Name: 2-cyclobutoxyacetic acid
• CAS No.: 189956-41-0
• Molecular Formula: C6H10O3
• Molecular Weight: 130
• Hs Code.: 2918990090
• Mol file: 189956-41-0.mol

Synonyms:2-cyclobutoxyacetic acid

Chemical Property of 2-cyclobutoxyacetic acid

Chemical Property:

• Boiling Point: 278.6±13.0 °C(Predicted)
• PKA: 3.55±0.10(Predicted)
• PSA: 46.53000
• Density: 1.17±0.1 g/cm3(Predicted)
• LogP: 0.64010
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-cyclobutoxyaceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-cyclobutoxyacetic acid

There total 4 articles about 2-cyclobutoxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cyclobutanol (2919-23-5) + bromoacetic acid (79-08-3) → 2-(cyclobutoxy)acetic acid (189956-41-0)

Guidance literature:

cyclobutanol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

bromoacetic acid; In tetrahydrofuran; at 0 - 20 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c01504

Reference yield:

tert-butyl 2-cyclobutoxyacetate → 2-(cyclobutoxy)acetic acid (189956-41-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 40 ℃; for 4h; Inert atmosphere;

Reference yield:

cyclobutanol (2919-23-5) + sodium monochloroacetic acid (3926-62-3) → 2-(cyclobutoxy)acetic acid (189956-41-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/S0960-894X(99)00365-0

upstream raw materials:

cyclobutanol

sodium monochloroacetic acid

bromoacetic acid